US 12,064,339 B2
Implantable scaffolds for treatment methods of sinusitus
Changcheng You, Northbridge, MA (US); Quynh Pham, Methuen, MA (US); and Danny Concagh, Medfield, MA (US)
Assigned to LYRA THERAPEUTICS, INC., Watertown, MA (US)
Filed by Lyra Therapeutics, Inc., Watertown, MA (US)
Filed on Sep. 28, 2020, as Appl. No. 17/034,383.
Application 17/034,383 is a continuation of application No. 16/199,670, filed on Nov. 26, 2018, granted, now 10,806,568.
Application 16/199,670 is a continuation of application No. 15/197,686, filed on Jun. 29, 2016, granted, now 10,219,894, issued on Mar. 5, 2019.
Claims priority of provisional application 62/332,134, filed on May 5, 2016.
Claims priority of provisional application 62/289,982, filed on Feb. 2, 2016.
Claims priority of provisional application 62/186,030, filed on Jun. 29, 2015.
Prior Publication US 2021/0068945 A1, Mar. 11, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61F 2/18 (2006.01); A61F 2/90 (2013.01); A61K 31/58 (2006.01); A61L 27/18 (2006.01); A61L 27/26 (2006.01); A61L 27/34 (2006.01); A61L 27/54 (2006.01); A61L 27/56 (2006.01); A61L 31/06 (2006.01); A61L 31/10 (2006.01)
CPC A61F 2/18 (2013.01) [A61F 2/90 (2013.01); A61K 31/58 (2013.01); A61L 27/18 (2013.01); A61L 27/26 (2013.01); A61L 27/34 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); A61L 31/06 (2013.01); A61L 31/10 (2013.01); A61F 2/186 (2013.01); A61F 2210/0004 (2013.01); A61F 2250/0031 (2013.01); A61F 2250/0067 (2013.01); A61L 2300/222 (2013.01); A61L 2300/41 (2013.01); A61L 2300/604 (2013.01); A61L 2300/608 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A method of treatment of a human patient, comprising:
a) providing a scaffold comprising
i) a first layer comprising mometasone furoate and a biodegradable polymer material and
ii) a therapeutic-agent-free polymer topcoat layer, said topcoat layer positioned on said first layer; and
b) delivering said scaffold to the middle meatus under conditions where the scaffold delivers said mometasone furoate from the middle meatus to the ethmoid sinuses of a human patient, wherein the scaffold is not placed in a sinus ostium.