US 12,064,264 B2
Pacifier sensor for biomarker monitoring
Joseph Wang, La Jolla, CA (US); Aida Martin Galan, La Jolla, CA (US); Juliane R. Sempionatto-Moreto, La Jolla, CA (US); Alberto Escarpa, Madrid (ES); Laura Garcia Carmona, Madrid (ES); and Maria Cristina Gonzalez, Madrid (ES)
Filed by The Regents of the University of California, Oakland, CA (US); and University of Alcala, Madrid (ES)
Filed on Apr. 30, 2021, as Appl. No. 17/246,453.
Claims priority of provisional application 63/018,343, filed on Apr. 30, 2020.
Prior Publication US 2021/0338157 A1, Nov. 4, 2021
Int. Cl. A61B 5/1486 (2006.01); A61B 5/00 (2006.01); A61B 5/145 (2006.01); A61B 5/1455 (2006.01); A61J 17/00 (2006.01)
CPC A61B 5/682 (2013.01) [A61B 5/0002 (2013.01); A61B 5/14507 (2013.01); A61B 5/14532 (2013.01); A61B 5/1455 (2013.01); A61B 5/1486 (2013.01); A61J 17/10 (2020.05); A61J 2200/70 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A sensor device capable of performing electrochemical measurements, comprising:
a flexible orthodontic device for placement in a patient's mouth, the flexible orthodontic device having a hole in an end configured to allow saliva to pass;
a plurality of valves to allow the saliva to pass in a forward direction through the flexible orthodontic device and not in a reverse direction, wherein each of the plurality of valves includes a first side and a second side wider than the first side, wherein at least one of the plurality of valves is placed after another valve such that the first side of a first valve of the plurality of valves is inside the second side of a second valve of the plurality of valves arranged next to the first valve; and
one of or more electrochemical or optical electrodes configured to contact the saliva, wherein the one or more electrochemical or optical electrodes are configured to determine a presence of one or more chemical biomarkers in the saliva.