US 12,064,235 B2
Digital qualimetric biomarkers for determining information processing speed
Mike Baker, Basel (CH); Shibeshih Mitiku Belachew, Basel (CH); Christian Gossens, Basel (CH); Michael Lindemann, Basel (CH); and Jörg Sprengel, Reinach (CH)
Assigned to Hoffman La Roche Inc., Newark, NJ (US)
Filed by Hoffmann-La Roche Inc., Little Falls, NJ (US)
Filed on Nov. 7, 2020, as Appl. No. 17/092,263.
Application 17/092,263 is a continuation of application No. PCT/EP2019/061819, filed on May 8, 2019.
Claims priority of application No. 18171567 (EP), filed on May 9, 2018.
Prior Publication US 2021/0059572 A1, Mar. 4, 2021
Int. Cl. A61B 5/11 (2006.01); A61B 5/00 (2006.01); A61B 5/16 (2006.01); G16H 20/70 (2018.01); G16H 50/20 (2018.01); G16H 50/30 (2018.01)
CPC A61B 5/1124 (2013.01) [A61B 5/162 (2013.01); A61B 5/4082 (2013.01); A61B 5/4088 (2013.01); G16H 20/70 (2018.01); G16H 50/20 (2018.01); G16H 50/30 (2018.01)] 25 Claims
OG exemplary drawing
 
1. A method for automatically assessing information processing speed in a test subject, comprising:
a) obtaining a dataset of cognitive oculomotor activity measurements from the test subject ;
b) determining a first qualimetric activity parameter for sensorial transmission, cognition and motoric output activity from the dataset of cognitive oculomotor activity measurements, wherein the first qualimetric activity parameter is based on a symbol to digit conversion;
c) determining a second qualimetric activity parameter for sensorial transmission and motoric output activity from the dataset of cognitive oculomotor activity measurements;
d) determining a third qualimetric activity parameter for cognition by comparing the first and the second qualimetric activity parameters to each other; and
e) assessing the information processing speed in the test subject based on the first, second and third qualimetric activity parameters.