US 12,064,208 B2
Time-of-flight optical measurement and decoding of fast-optical signals
Jamu Alford, Simi Valley, CA (US); Adam Marblestone, Arlington, MA (US); Ivo Vellekoop, Enschede (NL); Daniel Sobek, Portola Valley, CA (US); Michael Henninger, Austin, TX (US); Brian Robinson, Ellicott City, MD (US); Yuecheng Shen, Guangzhou University (CN); and Roarke Horstmeyer, Durham, NC (US)
Assigned to HI LLC, Los Angeles, CA (US)
Filed by HI LLC, Los Angeles, CA (US)
Filed on May 18, 2022, as Appl. No. 17/663,992.
Application 17/663,992 is a continuation of application No. 16/533,133, filed on Aug. 6, 2019, granted, now 11,412,930.
Claims priority of provisional application 62/722,152, filed on Aug. 23, 2018.
Prior Publication US 2023/0301515 A1, Sep. 28, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/00 (2006.01); A61B 5/026 (2006.01)
CPC A61B 5/0004 (2013.01) [A61B 5/0066 (2013.01); A61B 5/0084 (2013.01); A61B 5/0261 (2013.01)] 16 Claims
OG exemplary drawing
 
1. An optical measurement system, comprising:
an optical source configured for delivering sample light in an anatomical structure, such that the sample light is scattered by the anatomical structure, resulting in physiological-encoded signal light that exits the anatomical structure;
an optical detector configured for detecting the physiological-encoded signal light
a processor configured for acquiring an initial time-of-flight (TOF) profile derived from the physiological-encoded signal light, the initial TOF profile having a shot noise variance, the processor further configured for applying a weighting function to the initial TOF profile to generate a weighted TOF profile that has a decreased shot noise variance, the processor further configured for processing the weighted TOF profile by reducing the weighted TOF profile to a single index value indicative of the one state of the physiological activity, and identifying one of a plurality of states of a physiological activity in the anatomical structure based on the single index value.