US 12,063,914 B2
DNA sequence that increases odorant receptor representation in the olfactory system
Paul Feinstein, New York, NY (US); and Charlotte D'Hulst, Brooklyn, NY (US)
Assigned to Paul Feinstein, New York, NY (US)
Filed by Research Foundation of the City University of New York, New York, NY (US)
Filed on Dec. 5, 2019, as Appl. No. 16/704,740.
Application 16/704,740 is a continuation of application No. 15/749,007, granted, now 10,512,253, previously published as PCT/US2016/045338, filed on Aug. 3, 2016.
Claims priority of provisional application 62/312,068, filed on Mar. 23, 2016.
Claims priority of provisional application 62/200,312, filed on Aug. 3, 2015.
Prior Publication US 2020/0093104 A1, Mar. 26, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. C12N 15/85 (2006.01); A01K 67/0275 (2024.01)
CPC A01K 67/0275 (2013.01) [C12N 15/85 (2013.01); C12N 15/8509 (2013.01); A01K 2217/072 (2013.01); A01K 2217/20 (2013.01); A01K 2227/10 (2013.01); A01K 2267/02 (2013.01)] 6 Claims
 
1. A vector comprising
(a) a M71 odorant receptor (OR) transgene backbone, wherein the M71 odorant receptor (OR) transgene backbone comprises the nucleotide sequence as set forth in SEQ ID NO: 13 or 14,
(b) at least four sequential repeats of a 21 base pair (bp) nucleotide sequence wherein each of the 21 bp sequential repeat consists of the nucleotide sequence as set forth in SEQ ID NO: 1,
(c) a transcription start site (TSS) disposed downstream of the at least four sequential repeats, and
(d) an odorant receptor coding sequence disposed downstream of the transcription start site.