CPC H01J 49/0027 (2013.01) [G01N 1/32 (2013.01); H01J 37/32009 (2013.01); H01J 2237/0807 (2013.01); H01J 2237/31745 (2013.01); H01J 2237/31749 (2013.01)] | 13 Claims |
1. A method of analyzing a biological sample, comprising:
providing at least one biological sample in frozen form;
milling the sample using a plasma ion beam comprising at least an O+ plasma to isolate at least a target in the sample from the rest of the sample, wherein the sample is milled at a mass removal rate of at least 100 μm3/second using the plasma ion beam, and wherein the target is cryogenically preserved for sensitive protein analysis; and
analyzing the isolated target with the sensitive protein analysis, wherein the sensitive protein analysis includes proteomic analysis and/or next-generation sequencing.
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