US 11,733,198 B2
Method for determining analyte concentration in a sample
Zuifang Liu, Inverness (GB); David McColl, Inverness (GB); Robert Donald, Inverness (GB); Anna Salgado, Inverness (GB); and Antony Smith, Inverness (GB)
Assigned to LIFESCAN IP HOLDINGS, LLC, Malvern, PA (US)
Filed by Lifescan IP Holdings, LLC, Malvern, PA (US)
Filed on Jun. 14, 2021, as Appl. No. 17/346,765.
Application 17/346,765 is a division of application No. 16/021,403, filed on Jun. 28, 2018, granted, now 11,035,819.
Prior Publication US 2021/0381998 A1, Dec. 9, 2021
Int. Cl. G01N 27/327 (2006.01); A61B 5/145 (2006.01); G01N 27/48 (2006.01); G01N 27/416 (2006.01)
CPC G01N 27/3274 (2013.01) [G01N 27/3273 (2013.01); A61B 5/14532 (2013.01); A61B 2562/0295 (2013.01); G01N 27/3272 (2013.01); G01N 27/3277 (2013.01); G01N 27/4168 (2013.01); G01N 27/48 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A method for determining a concentration of an analyte in a fluidic sample, the method comprising:
applying the fluidic sample to a biosensor, the biosensor comprising an electrochemical cell having electrodes;
applying a voltage waveform comprising at least a first predetermined voltage applied during a first time interval and a second predetermined voltage different from the first predetermined voltage applied during a second time interval;
measuring at least first current values during the first time interval and second current values during the second time interval;
determining a turning point time during the first time interval at which the measured first current values transition from a first profile to a second profile; and
estimating a physical characteristic of the sample based on the turning point time, the first measured current values and the second measured current values;
if the estimated physical characteristic of the sample is in a first range, calculating the concentration of the analyte in the sample using a first model based on the first measured current values and the second measured current values; and
if the estimated physical characteristic of the sample is in a second range, calculating the concentration of the analyte in the sample using a second model based on the determined turning point time, the first measured current values and second measured current values.