CPC C12N 9/22 (2013.01) [C07K 14/005 (2013.01); C07K 14/315 (2013.01); C12N 15/63 (2013.01); C12N 2795/10322 (2013.01)] | 4 Claims |
1. A method for modulating the activity of a Cas endonuclease with a target polynucleotide in a cell, comprising providing an anti-CRISPR (ACR) polypeptide having an amino acid sequence at least 90% identical to SEQ ID NO:8 to the cell, wherein the ACR polypeptide decreases the activity of the Cas endonuclease in the cell compared to a control cell comprising the Cas endonuclease but not comprising the ACR polypeptide.
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