US 11,732,093 B2
Cross polymers composed of polysaccharides and polyamino acids, and uses thereof
María Jesús Vicent Docón, Valencia (ES); Vicent Josep Nebot Carda, Valencia (ES); Daniel Morelló Bolumar, Valencia (ES); and Richard Marc England, Valencia (ES)
Assigned to POLYPEPTIDE THERAPEUTIC SOLUTIONS S.L., Paterna (ES)
Appl. No. 16/634,013
Filed by POLYPEPTIDE THERAPEUTIC SOLUTIONS S.L., Paterna (ES)
PCT Filed Jul. 6, 2018, PCT No. PCT/EP2018/068327
§ 371(c)(1), (2) Date Jan. 24, 2020,
PCT Pub. No. WO2019/020344, PCT Pub. Date Jan. 31, 2019.
Claims priority of application No. 17382498 (EP), filed on Jul. 26, 2017.
Prior Publication US 2020/0207922 A1, Jul. 2, 2020
Int. Cl. C08G 81/00 (2006.01); A61K 47/64 (2017.01); A61K 8/88 (2006.01); C08G 69/10 (2006.01)
CPC C08G 81/00 (2013.01) [A61K 8/88 (2013.01); A61K 47/645 (2017.08); C08G 69/10 (2013.01); A61K 2800/10 (2013.01)] 19 Claims
 
1. A cross-polymer comprising two or more recurring units of formula (I) below:

OG Complex Work Unit Chemistry
or its salt, solvate or isomer, wherein:
PLS is a radical of a polysaccharide;
PLS-RU is a radical of a repeating unit of the polysaccharide;
PAA is a radical of a polyamino acid comprising at least two amino acid units, wherein the polyamino acid is selected from the group consisting of homo-polyamino acids, random co-polyamino acids, and block co-polyamino acids, with the proviso that the homo-polyamino acid is not polycationic;
AA is a radical of an amino acid unit of the polyamino acid;
subscript x of the radical (AA) is an integer selected from 1 to 200;
subscript v of the radical [(PAA)-(AA)x] is an integer selected from 1 to 48;
subscript w of the radical (PLS-RU) is an integer selected from 1 to 200;
In is a ROP initiator which comprises a terminal X group per each [(PAA)-(AA)] radical, wherein each terminal X group is directly bound to each [(PAA)-(AA)] radical, and wherein the terminal X group is selected from the group consisting of —NH—, —O—, —S—, and combinations thereof;
CL is a radical of a compound selected from the group consisting of (C1-C500)-alkyl, wherein two or more hydrogens are replaced by a moiety selected from
(1) (C1-C500)-alkyl; (2) (C3-C30)-cycloalkyl, (3) C-radical derived from a ring system with 1-6 rings, each ring being independently saturated, partially unsaturated or aromatic, the rings of the ring system being isolated or fused and each ring having 3-20 elements each element independently selected from the group consisting of C, CH, CH2, CO, O, S, N and NH, (4) OH, (5) NRaRb, (6) ONRcRd, (7) CN, (8) halide, (9) SH2, (10) SReRf, (11) N(H)NH2, (12) RgCORh, (13) COORi, (14) CON(Rj)(Rk), (15) RlN(Rm)CON(Rn)(R′n), (16) (C1-C30)-alkenyl(C1-C30)-alkene, (17) (C1-C30)-alkyne, (18) N3, (19) RoCH(ORp)(ORq), (20) RrCH(SRs)(SRt), (21) RuB(ORv)(ORw), and (22) CORx, wherein:
one or more carbons are optionally independently replaced by a moiety selected from (C3-C30)-cycloalkyl, aryl, aryl-(C1-C30)-alkyl, NRyRz, CO, O, S, S(O), S(O2), B, P and (O—CH2—CH2)A;
subscript A of the radical (O—CH2—CH2) is an integer selected from 1 to 500;
Ra, Rb, Rc, Rd, Re, Rf, Rh, Ri, Rj, Rk, Rm, Rn, R′n, Rp, Rq, Rs, Rt, Rv, Rw, Rx, Ry and Rz are radicals independently selected from the group consisting of H, (C1-C30)-alkyl, (C1-C30)-alkylphenyl, phenyl-(C1-C30)-alkyl, and (C3-C8)-cycloalkyl, wherein one or more carbons are optionally independently replaced by a heteroatom selected from the group consisting of O, S, S(O), S(O2), halide, N, NH, P, and CO;
Rg, Rl, Ro, Rr and Ru are radicals independently selected from the group consisting of (C1-C30)-alkyl, (C1-C30)-alkylphenyl, phenyl-(C1-C30)-alkyl, and (C3-C8)-cycloalkyl, wherein, one or more carbons are optionally independently replaced by a heteroatom selected from the group consisting of O, S, S(O), S(O2), halide, N, NH, P, and CO;
with the proviso that CL may be present or not present, wherein if CL is not present, the radical PLS-RU is directly bonded to a radical AA.