US 11,732,084 B2
Anti-microbial hydrogel
Arn Mignon, Geraardsbergen (BE); Tom Gheysens, Ghent (BE); Sandra Van Vlierberghe, Sint-Niklaas (BE); and Peter Dubruel, Ghent (BE)
Assigned to UNIVERSITEIT GENT, Ghent (BE)
Appl. No. 17/640,518
Filed by UNIVERSITEIT GENT, Ghent (BE)
PCT Filed Sep. 11, 2020, PCT No. PCT/EP2020/075475
§ 371(c)(1), (2) Date Mar. 4, 2022,
PCT Pub. No. WO2021/048357, PCT Pub. Date Mar. 18, 2021.
Claims priority of application No. 19196659 (EP), filed on Sep. 11, 2019.
Prior Publication US 2022/0325030 A1, Oct. 13, 2022
Int. Cl. A61L 26/00 (2006.01); C08G 18/75 (2006.01); C08F 290/06 (2006.01); C08G 18/48 (2006.01); C08J 3/075 (2006.01); C08K 5/00 (2006.01)
CPC C08G 18/756 (2013.01) [A61L 26/00 (2013.01); A61L 26/008 (2013.01); A61L 26/0052 (2013.01); A61L 26/0066 (2013.01); C08F 290/067 (2013.01); C08G 18/4833 (2013.01); C08J 3/075 (2013.01); C08K 5/0058 (2013.01); A61L 2300/106 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A hydrogel comprising:
an antimicrobial agent; and
a cross-linkable urethane-based polymer represented by formula (I):

OG Complex Work Unit Chemistry
where:
each occurrence of X and Y is independently a moiety comprising one or more group chosen from acrylate groups, (multi)methacrylate groups, (multi)acrylate group, thiolactones, or thiol-ene crosslinkable groups;
each occurrence of Spacer is independently selected from the group consisting of oligo(ethylene oxide), oligo(propylene oxide), oligo(caprolactone), oligo(lactide), and oligo(glycolide);
m and n are each independently from 1 to 6;
p is from 1 to 10; and
each occurrence of Backbone is independently selected from the group consisting of polyethylene glycol), poly(vinyl pyrrolidone), poly(N-vinyl caprolactam), and combinations thereof.