CPC C07K 16/2878 (2013.01) [C07K 16/2896 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/34 (2013.01); C07K 2317/55 (2013.01); C07K 2317/565 (2013.01); C07K 2317/73 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)] | 7 Claims |
1. An isolated human anti-CD27 antibody or antigen-binding fragment thereof, comprising a light chain variable region and a heavy chain variable region, said light chain variable region comprising:
a complementarity determining region light chain 1 (CDRL1) amino acid sequence selected from the group consisting of SEQ ID NOS: 24-36, 153, and 155;
a CDRL2 amino acid sequence selected from the group consisting of SEQ ID NOs: 37-40 and 154; and
a CDRL3 amino acid sequence of SEQ ID NO: 41, and said heavy chain variable region comprising:
a CDRH1 amino acid sequence selected from the group consisting of SEQ ID NOs: 1 and 2;
a CDRH2 amino acid sequence selected from the group consisting of SEQ ID NOs: 3-22, 151, and 152; and
a CDRH3 amino acid sequence selected from the group consisting of SEQ ID NOS: 23 and 162.
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