US 11,732,003 B2
Mechanical method of maintaining narrow residence time distributions in continuous flow systems
Ronald Tuccelli, Burlington, MA (US); John Caulmare, Burlington, MA (US); Luc Messier, Burlington, MA (US); Melissa Holstein, Burlington, MA (US); Christopher Gillespie, Burlington, MA (US); and Roger Hill, Burlington, MA (US)
Assigned to EMD Millipore Corporation, Burlington, MA (US)
Appl. No. 16/610,616
Filed by EMD Millipore Corporation, Burlington, MA (US)
PCT Filed Apr. 18, 2018, PCT No. PCT/US2018/028101
§ 371(c)(1), (2) Date Nov. 4, 2019,
PCT Pub. No. WO2018/208447, PCT Pub. Date Nov. 15, 2018.
Claims priority of provisional application 62/504,633, filed on May 11, 2017.
Prior Publication US 2020/0172568 A1, Jun. 4, 2020
Int. Cl. A61L 2/00 (2006.01); A61L 2/26 (2006.01); B01D 15/24 (2006.01); B01L 3/00 (2006.01); C12N 7/00 (2006.01); C07K 1/22 (2006.01); B01D 15/36 (2006.01); B01D 15/38 (2006.01)
CPC C07K 1/22 (2013.01) [A61L 2/0088 (2013.01); A61L 2/26 (2013.01); B01D 15/245 (2013.01); B01D 15/361 (2013.01); B01D 15/3809 (2013.01); B01L 3/502 (2013.01); C12N 7/00 (2013.01); A61L 2202/21 (2013.01); B01L 2400/0481 (2013.01); B01L 2400/082 (2013.01); C12N 2740/10063 (2013.01); C12N 2740/10064 (2013.01); C12N 2795/00063 (2013.01); C12N 2795/00064 (2013.01)] 3 Claims
OG exemplary drawing
 
1. A method for inactivating one or more viruses in a sample containing a target molecule, wherein the method comprises continuously exposing said sample to virus inactivation conditions, followed by causing the sample to flow in a flow channel in discrete packets by applying compressive force to the flow channel during a process for purifying said target molecule, wherein said compressive force is caused by compressing tubing coiled around a mandrel, said tubing defining said flow channel.