	US 11,731,983 B2
	Production method of thienopyrimidine derivative
Kazuhiro Miwa, Osaka (JP)
Assigned to Takeda Pharmaceutical Company Limited, Osaka (JP)
Filed by Takeda Pharmaceutical Company Limited, Osaka (JP)
Filed on Jun. 16, 2021, as Appl. No. 17/349,584.
Application 16/116,804 is a division of application No. 15/481,505, filed on Apr. 7, 2017, granted, now 10,150,778, issued on Dec. 11, 2018.
Application 15/481,505 is a division of application No. 14/432,188, granted, now 9,758,528, issued on Sep. 12, 2017, previously published as PCT/JP2013/077013, filed on Sep. 27, 2013.
Application 17/349,584 is a continuation of application No. 16/710,390, filed on Dec. 11, 2019, granted, now 11,053,257, issued on Jul. 6, 2021.
Application 16/710,390 is a continuation of application No. 16/116,804, filed on Aug. 29, 2018, granted, now 10,544,160, issued on Jan. 28, 2020.
Claims priority of application No. 2012/217679 (JP), filed on Sep. 28, 2012.
Prior Publication US 2022/0135585 A1, May 5, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 495/04 (2006.01); C07D 333/38 (2006.01); C07D 409/12 (2006.01)

CPC C07D 495/04 (2013.01) [C07D 333/38 (2013.01); C07D 409/12 (2013.01)]

10 Claims

1. A method of producing 6-(4-aminophenyl)-1-(2,6-difluorobenzyl)-5-dimethylaminomethyl-3-(6-methoxypyridazin-3-yl)thieno[2,3-d]pyrimidine -2,4(1H,3H)-dione, or a salt thereof, which comprises subjecting 1-(2,6-difluorobenzyl)-5-dimethylaminomethyl-3-(6-methoxypyridazin-3-yl)-6-(4-nitrophenyl)thieno[2,3-d]pyrimidine -2,4(1H,3H)-dione, or a salt thereof, to a reduction reaction.