CPC C07D 417/14 (2013.01) [A61P 31/04 (2018.01); C07D 409/14 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01)] | 12 Claims |
1. A compound having a formula
or an analog thereof or a pharmaceutically acceptable salt thereof, wherein
X is O;
R1 is methyl;
R2 is an alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, heterocyclyl, cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, acyl, aryl, heteroaryl, arylalkyl, arylalkenyl, or arylalkynyl;
R3 represents four substituents, each independently selected from the group consisting of hydrogen, deuterium, halo, azido, cyano, nitro, hydroxy, amino, thio, carboxy, ester, amide, and derivatives thereof, and acyl, sulfoxyl, sulfonyl, phosphate, phosphoryl, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, heterocyclyl, cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, aryl, heteroaryl, arylalkyl, arylalkenyl, and arylalkynyl or any two adjacent substituents are taken together with the attached carbons form cyclic or heterocyclic moiety; and
R4 is an acyl, ester, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, heterocyclyl, cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, aryl, heteroaryl, arylalkyl, arylalkenyl, and arylalkynyl, and wherein R4 is not a thiophene ring or a substituted thiophene ring, wherein R4 is optionally substituted with one or more of a halogen that is not fluoride, an alkoxy group, a hydroxyl group, an aryloxy group, an aralkyloxy group, a carbonyl group, a thiol, a cyano, an acyl, and an amino group.
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