CPC C07D 417/12 (2013.01) [C07D 213/127 (2013.01); C07F 7/10 (2013.01)] | 18 Claims |
1. A process, comprising
(i) combining an alkyl lithium and a compound having Formula II:
in a solvent at a temperature from about −20° C. to about −85° C. to give a first reaction mixture, wherein PG is a protecting group and LG1 is bromide or iodide;
(ii) adding ethylene oxide as is to said first reaction mixture at said temperature to give a second reaction mixture; and
(iii) adding a copper(I)salt to said second reaction mixture at said temperature to give a third reaction mixture comprising a compound having Formula III:
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