CPC C07D 263/58 (2013.01) [C07C 237/42 (2013.01); C07C 255/60 (2013.01); C07C 327/42 (2013.01); C07D 209/08 (2013.01)] | 14 Claims |
1. A compound selected from any one of the following compounds:
or a pharmaceutically acceptable salt thereof, wherein:
Z1 is selected from the group consisting of O and S;
L1 is selected from the group consisting of methylene, methylmethylene, fluoromethylmethylene, fluoromethylene, difluoromethylene, and aminomethylene;
L2 is selected from the group consisting of NRN1C(O) and NRN1C(S);
RN1 and RN2 are each independently selected from the group consisting of H and C1-4 alkyl;
each R1 is independently selected from the group consisting of C1-4 haloalkyl, halo, CN, NO2, NH2, —COOH, —CONH2, and OH; and
each R2 is independently selected from the group consisting of halo, CN, NH2, —COOH, —CONH2, —C(O)C1-4 haloalkyl, —NHC(O)C1-4 haloalkyl, —NHSO2-C1-4 alkyl, and phenoxy;
wherein either R1 is CN or R2 is CN or phenoxy; and
wherein the compound of Formula I is not:
|