	US 11,730,861 B2
	Hydrogel devices and methods of making and use thereof
Aldona Jedrysiak Spiegel, Houston, TX (US)
Assigned to The Methodist Hospital System, Houston, TX (US)
Filed by The Methodist Hospital System, Houston, TX (US)
Filed on Jul. 26, 2022, as Appl. No. 17/873,553.
Claims priority of provisional application 63/255,565, filed on Oct. 14, 2021.
Prior Publication US 2023/0119855 A1, Apr. 20, 2023
Int. Cl. A61L 27/52 (2006.01); A61L 27/38 (2006.01); A61L 27/54 (2006.01); B33Y 80/00 (2015.01)

CPC A61L 27/52 (2013.01) [A61L 27/3808 (2013.01); A61L 27/54 (2013.01); A61L 2300/64 (2013.01); A61L 2400/18 (2013.01); A61L 2430/04 (2013.01); B33Y 80/00 (2014.12)]

30 Claims

1. A device comprising:

a continuous hydrogel matrix;

a first chamber in the hydrogel matrix; and

a second chamber in the hydrogel matrix;

wherein the first chamber and the second chamber are each independently perfusable;

wherein the first chamber is fluidly independent from the second chamber;

wherein the first chamber is configured to be at least partially filled with adipose tissue;

wherein the second chamber is configured to be at least partially filled with an oxygenated fluid;

wherein the first chamber is defined by a first border;

wherein the second chamber is defined by a second border; and

wherein the first chamber and the second chamber are spaced apart from each other by an average distance of from 50 micrometers (microns, μm) to 800 μm as measured from the first border to the second border.