	US 11,730,738 B2
	Alpha polyglutamated pralatrexate and uses thereof
Clet Niyikiza, Gulph Mills, PA (US); and Victor Mandla Moyo, Ringoes, NJ (US)
Assigned to L.E.A.F. HOLDINGS GROUP LLC, Gulph Mills, PA (US)
Appl. No. 16/967,303
Filed by L.E.A.F. HOLDINGS GROUP LLC, Gulph Mills, PA (US)
PCT Filed Feb. 7, 2019, PCT No. PCT/US2019/016971 § 371(c)(1), (2) Date Aug. 4, 2020, PCT Pub. No. WO2019/157129, PCT Pub. Date Aug. 15, 2019.
Claims priority of provisional application 62/764,943, filed on Aug. 17, 2018.
Claims priority of provisional application 62/702,732, filed on Jul. 24, 2018.
Claims priority of provisional application 62/662,374, filed on Apr. 25, 2018.
Claims priority of provisional application 62/630,637, filed on Feb. 14, 2018.
Claims priority of provisional application 62/627,741, filed on Feb. 7, 2018.
Claims priority of provisional application 62/627,731, filed on Feb. 7, 2018.
Prior Publication US 2020/0360390 A1, Nov. 19, 2020
Int. Cl. A61K 31/519 (2006.01); A61K 47/69 (2017.01); A61K 47/54 (2017.01); A61K 47/64 (2017.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01); A61K 9/127 (2006.01); A61K 47/26 (2006.01); A61K 49/00 (2006.01)

CPC A61K 31/519 (2013.01) [A61K 9/1271 (2013.01); A61K 47/26 (2013.01); A61K 47/542 (2017.08); A61K 47/64 (2017.08); A61K 47/6849 (2017.08); A61K 47/6913 (2017.08); A61K 49/0084 (2013.01); A61P 35/00 (2018.01)]

47 Claims

1. A liposomal composition comprising an alpha polyglutamated pralatrexate encapsulated by a liposome, wherein the alpha polyglutamated pralatrexate comprises four or more glutamyl groups having an alpha carboxyl group linkage.