CPC A61B 17/1128 (2013.01) [A61L 27/24 (2013.01); A61L 27/26 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); A61B 2017/00004 (2013.01); A61B 2017/1132 (2013.01); A61L 2300/236 (2013.01); A61L 2300/252 (2013.01); A61L 2430/32 (2013.01)] | 20 Claims |
1. A nerve guide conduit comprising:
an outer collagen tube;
an internal matrix formed within the outer collagen tube by filling the collagen tube with a slurry comprising collagen, glycosaminoglycan, fibronectin, laminin-1, and laminin-2, wherein the glycosaminoglycan, fibronectin, laminin-1, and laminin-2 have a dry weight basis in the ratio of about 1:1:1:1; freezing the slurry along an axial direction of the slurry, with the slurry having no detectable radial thermal gradient, to form a frozen slurry having parallel axially aligned crystals; and freeze drying the collagen tube and the frozen slurry to remove the parallel axially aligned crystals and form the internal matrix having parallel axially aligned internal matrix pores that span one end of the matrix to the other.
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