US 11,730,406 B2
Thermally stable glucose limiting membrane for glucose sensors
Jenn-Hann Larry Wang, Northridge, CA (US); Dero Hovanes, Glendale, CA (US); and Poonam S. Gulati, La Canada, CA (US)
Assigned to MEDTRONIC MINIMED, INC., Northridge, CA (US)
Filed by Medtronic MiniMed, Inc., Northridge, CA (US)
Filed on Sep. 17, 2021, as Appl. No. 17/477,944.
Application 17/477,944 is a division of application No. 15/981,681, filed on May 16, 2018, granted, now 11,134,872.
Application 15/981,681 is a continuation in part of application No. 15/612,759, filed on Jun. 2, 2017, granted, now 11,179,078.
Claims priority of provisional application 62/346,301, filed on Jun. 6, 2016.
Prior Publication US 2022/0000401 A1, Jan. 6, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/1486 (2006.01); A61B 5/145 (2006.01); C08G 18/72 (2006.01); C08L 75/12 (2006.01); C08G 18/32 (2006.01); C08G 18/44 (2006.01); C08G 18/40 (2006.01); C08G 18/73 (2006.01); C08G 18/61 (2006.01); A61B 5/00 (2006.01); C08G 18/76 (2006.01); C08G 18/50 (2006.01); C08G 77/458 (2006.01); C08G 77/448 (2006.01)
CPC A61B 5/14865 (2013.01) [A61B 5/14532 (2013.01); A61B 5/686 (2013.01); C08G 18/3228 (2013.01); C08G 18/4009 (2013.01); C08G 18/44 (2013.01); C08G 18/5024 (2013.01); C08G 18/61 (2013.01); C08G 18/72 (2013.01); C08G 18/724 (2013.01); C08G 18/73 (2013.01); C08G 18/7671 (2013.01); C08L 75/12 (2013.01); A61B 5/6876 (2013.01); A61B 2562/125 (2013.01); C08G 77/448 (2013.01); C08G 77/458 (2013.01)] 13 Claims
 
1. An amperometric analyte sensor comprising:
a base layer;
a conductive layer disposed on the base layer and comprising a working electrode;
an analyte sensing layer disposed on the conductive layer; and
an analyte modulating layer disposed on the analyte sensing layer, wherein the analyte modulating layer:
(a) is formed by a reaction mixture comprising:
from 17% to 23% weight percent hexamethylene diisocyanate;
from 0% to 8.5% weight percent methylene diphenyl diisocyanate;
from 14% to 48% weight percent polydimethylsiloxane having amino terminal groups; and
from 7.5% to 19% weight percent poly(1,6-hexyl carbonate) diol; and
a catalyst present in the reaction mixture in amounts less than 0.2% of reaction mixture components; and
(b) exhibits a greater thermal stability than a comparable analyte modulating layer formed from a reaction mixture where the catalyst is present in the formulation in amounts greater than or equal to 0.2% of the reaction mixture.