US 11,730,405 B2
Body fluid leakage detection aqueous composition
Henrik Johansson, Kristianstad (SE); Peter Schuisky, Tjörnarp (SE); Thomas Pausch, Heidelberg (DE); and Thilo Hackert, Heidelberg (DE)
Assigned to MAGLE CHEMOSWED HOLDING AB, Malmo (SE); and UNIVERSITÄT HEIDELBERG, Heidelberg (DE)
Filed by MAGLE CHEMOSWED HOLDING AB, Malmö (SE); and UNIVERSITÄT HEIDELBERG, Heidelberg (DE)
Filed on Dec. 3, 2020, as Appl. No. 17/110,498.
Application 17/110,498 is a continuation of application No. 16/478,629, granted, now 10,869,622, previously published as PCT/EP2018/086183, filed on Dec. 20, 2018.
Claims priority of application No. 17208850 (EP), filed on Dec. 20, 2017.
Prior Publication US 2021/0153789 A1, May 27, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/00 (2006.01); A61B 5/145 (2006.01); A61B 5/1473 (2006.01); A61B 17/06 (2006.01); A61B 17/064 (2006.01); A61K 49/00 (2006.01)
CPC A61B 5/14539 (2013.01) [A61B 5/1473 (2013.01); A61B 17/0644 (2013.01); A61B 17/06166 (2013.01); A61K 49/006 (2013.01)] 15 Claims
 
1. A body fluid leakage detection aqueous composition, the composition comprising a gelling agent, increasing a viscosity of the composition, wherein the gelling agent is cross-linked starch microspheres or cross-linked dextran microspheres, and buffering species, the composition thereby being buffered, wherein the composition further comprises a pH-indicator, wherein a pH of the composition is at least 0.1 pH units lower, or higher, than a pKa of the pH-indicator, and wherein the volume based mean diameter (D[4,3]), as determined in accordance with ISO 13 320:2009 by using laser diffraction, of the cross-linked starch microspheres, or the cross-linked dextran microspheres, as present in the composition, is 100 to 1000 μm.