CPC A01K 67/0275 (2013.01) [A61K 49/0008 (2013.01); C07K 14/78 (2013.01); A01K 2217/00 (2013.01); A01K 2217/056 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0306 (2013.01)] | 20 Claims |
1. An isolated mouse one-cell stage embryo whose genome comprises a mutation in the penultimate exon of the endogenous fibrillin-1 (Fbn1) gene,
wherein the mutation results in disruption or ablation of the asprosin C-terminal cleavage product of pro-fibrillin-1,
wherein expression of the mutant Fbn1 gene results in a C-terminally truncated Fbn1 protein, and
wherein a mouse generated from the isolated mouse one-cell stage embryo exhibits decreased body weight, decreased lean mass, and decreased fat mass when compared to a wild-type mouse.
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