| CPC G01N 35/1072 (2013.01) [G01N 1/40 (2013.01); G01N 35/1011 (2013.01); G01N 2030/525 (2013.01); G01N 2030/528 (2013.01); G01N 2035/00564 (2013.01); G01N 2035/1013 (2013.01); G01N 2035/1058 (2013.01)] | 28 Claims |

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1. A combination for use in an automated chemical analyzer having a sample metering device comprising:
a mixing cup, the mixing cup defining an interior cavity; and
an insert mounted within the interior cavity of the mixing cup wherein the insert includes one or more side walls, a top wall and a bottom wall disposed opposite the top wall, the one or more side walls extending between the top wall and the bottom wall; and
a porous matrix formed of or carrying in an immobilized state functionalized particles having properties such that a targeted component of a liquid sample adheres to the functionalized particles, the porous matrix having a porosity that allows the liquid sample to flow therethrough, and wherein the insert is formed with a generally frusto-conical shape and includes a generally circular upper portion having a first diameter and situated at or near the top wall thereof, a tapered middle portion of decreasing diameter, extending from the upper portion, and a generally cylindrical lower portion extending from the middle portion and situated at or near the bottom wall thereof, the lower portion having a second diameter which is less than the first diameter of the upper portion.
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