US 12,392,772 B2
Method for detection and separation of enantiomers using vesicle-like nanostructures self-assembled from Janus nanoparticles
Shaowei Chen, Santa Cruz, CA (US); and Jia-En Lu, Santa Cruz, CA (US)
Assigned to The Regents of the University of California, Oakland, CA (US)
Appl. No. 16/975,604
Filed by The Regents of the University of California, Oakland, CA (US)
PCT Filed Feb. 14, 2019, PCT No. PCT/US2019/017926
§ 371(c)(1), (2) Date Aug. 25, 2020,
PCT Pub. No. WO2019/164734, PCT Pub. Date Aug. 29, 2019.
Claims priority of provisional application 62/635,217, filed on Feb. 26, 2018.
Prior Publication US 2020/0400660 A1, Dec. 24, 2020
Int. Cl. G01N 33/543 (2006.01); G01N 21/19 (2006.01)
CPC G01N 33/54346 (2013.01) [G01N 21/19 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A method for processing an analyte, the method comprising:
adding a plurality of amphiphilic nanoparticles to a solvent to form a mixture, wherein each amphiphilic nanoparticle of the plurality of amphiphilic nanoparticles includes a gold core having a first surface portion and a second surface portion, the first surface portion functionalized with 1-hexanethiolate and the second surface portion functionalized 3-mercapto-1,2-propanediol via interfacial ligand exchange reaction and the plurality of amphiphilic nanoparticles self-assemble into a plurality of enantioselective, vesicle-like nanostructures without assistance of a template or a scaffold;
adding an analyte to the mixture to form an analyte mixture, wherein molecules of the analyte bind with the plurality of enantioselective, vesicle-like nanostructures;
obtaining a test circular dichroism spectrum of the analyte mixture; and
determining an enantiomeric property of the analyte based on a comparison of a baseline circular dichroism spectrum of the mixture to the test circular dichroism spectrum of the analyte mixture.