	US 12,392,055 B2
	Production method of innovative nanofiber medical textile material with transdermal-drug release properties
Funda Cengiz Çallioğlu, Isparta (TR); and Hülya Kesici Güler, Isparta (TR)
Assigned to SÜLEYMAN DEMIREL ÜNIVERSITESI IDARI VE MALI ISLER DAIRE BASKANLIGI GENELSEKRETERLIK, Isparta (TR)
Appl. No. 18/292,885
Filed by SÜLEYMAN DEMİREL ÜNİVERSİTESİ İDARİ VE MALİ İŞLER DAİRE BAŞKANLIǦI GENELSEKRETERLIK, Isparta (TR)
PCT Filed Nov. 15, 2022, PCT No. PCT/TR2022/051298 § 371(c)(1), (2) Date Jan. 26, 2024, PCT Pub. No. WO2023/086069, PCT Pub. Date May 19, 2023.
Prior Publication US 2024/0360593 A1, Oct. 31, 2024
Int. Cl. D01D 5/00 (2006.01); A61K 9/70 (2006.01); A61K 31/7052 (2006.01); A61K 47/42 (2017.01); D01F 6/56 (2006.01); D06M 13/372 (2006.01); D06M 23/10 (2006.01); D06M 101/18 (2006.01)

CPC D01D 5/0007 (2013.01) [A61K 9/7007 (2013.01); A61K 9/7084 (2013.01); A61K 31/7052 (2013.01); A61K 47/42 (2013.01); D01F 6/56 (2013.01); D06M 13/372 (2013.01); D06M 23/10 (2013.01); D06M 2101/18 (2013.01); D06M 2200/00 (2013.01); D10B 2211/20 (2013.01); D10B 2321/12 (2013.01); D10B 2509/00 (2013.01)]

9 Claims

1. A production method of drug-loaded, PVP/GEL-based, nanofiber medical textile surfaces that can provide transdermal drug delivery as burst or controlled release, the method comprising:

a) preparing polymer solutions containing PVP (polyvinylpyrrolidone) with a concentration of 12 wt % and GEL (gelatin) with a concentration of 0.72 wt %,

b) producing nanofibers from the prepared polymer solutions by atmosphere-controlled horizontal needle fiber spinning of an electrospinning set up,

c) obtaining PVP/GEL nanofibers by performing a cross-linking process of the produced nanofibers in two steps to maintain the stability of the produced nanofibers in aqueous environments, and

d) coating a drug active substance as a thin film on the obtained PVP/GEL nanofibers by USP (ultrasonic spray pyrolysis) method.