US 12,391,990 B2
Determination of magnesium body concentration
Qi Dai, Nashville, TN (US); Chang Yu, Nashville, TN (US); Martha Shrubsole, Nashville, TN (US); Xiangzhu Zhu, Nashville, TN (US); and Douglas Seidner, Nashville, TN (US)
Assigned to Vanderbilt University, Nashville, TN (US)
Appl. No. 17/621,996
Filed by Vanderbilt University, Nashville, TN (US)
PCT Filed Jun. 24, 2020, PCT No. PCT/US2020/039421
§ 371(c)(1), (2) Date Dec. 22, 2021,
PCT Pub. No. WO2020/264023, PCT Pub. Date Dec. 30, 2020.
Claims priority of provisional application 63/042,878, filed on Jun. 23, 2020.
Claims priority of provisional application 62/865,544, filed on Jun. 24, 2019.
Prior Publication US 2022/0267851 A1, Aug. 25, 2022
Int. Cl. C12Q 1/6883 (2018.01); A61K 33/06 (2006.01); G16B 20/00 (2019.01)
CPC C12Q 1/6883 (2013.01) [A61K 33/06 (2013.01); G16B 20/00 (2019.02); C12Q 2600/154 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A method for predicting and treating magnesium deficiency in a subject, said method comprising:
a) detecting methylation at CpG sites in DNA obtained from a biological sample from the subject, wherein the subject is in need of assessment for magnesium deficiency status; and
b) identifying the subject as being in need of magnesium supplementation when methylation is found at the CpG site: cg00430271 or cg25731074; and
c) administering an effective amount of magnesium to the identified subject.