	US 12,391,962 B2
	Targeting peptide to deliver a compound to oocytes
Jason Laurence Rasgon, State College, PA (US); Duverney De Jesus Chaverra Rodriguez, State College, PA (US); Grant Leslie Hughes, Wirral (GB); and Chan Chin Heu, Bellefonte, PA (US)
Assigned to THE PENN STATE RESEARCH FOUNDATION, University Park (PA)
Filed by THE PENN STATE RESEARCH FOUNDATION, University Park, PA (US)
Filed on Apr. 30, 2020, as Appl. No. 15/929,408.
Application 15/929,408 is a continuation of application No. PCT/US2018/057988, filed on Oct. 29, 2018.
Claims priority of provisional application 62/578,805, filed on Oct. 30, 2017.
Prior Publication US 2020/0299731 A1, Sep. 24, 2020
Int. Cl. C12N 15/90 (2006.01); A01K 67/68 (2025.01); C07K 14/435 (2006.01); C12N 9/22 (2006.01)

CPC C12N 15/902 (2013.01) [A01K 67/68 (2025.01); C12N 9/22 (2013.01); A01K 2217/072 (2013.01); A01K 2227/706 (2013.01); C07K 14/43581 (2013.01); C12N 2310/20 (2017.05); Y02A 50/30 (2018.01)]

22 Claims

1. A method for delivery of one or more molecules of interest to an oocyte of an animal, the method comprising,

injecting into a vitellogenic female animal a functional fragment of a yolk protein precursor (YPP) linked to said one or more molecules of interest,

wherein the YPP is a Drosophila Yolk Protein 1 (YP1) and wherein the functional fragment has 100% sequence identity to SEQ ID NO: 2 or SEQ ID NO: 3 and is capable of targeting the one or more molecules of interest to the oocyte.