US 12,391,833 B2
Polymeric dyes with linker groups comprising deoxyribose
Sharat Singh, Los Altos Hills, CA (US); Tracy Matray, Snohomish, WA (US); Michael Vanbrunt, Bothell, WA (US); and John McCutcheon, Shoreline, WA (US)
Assigned to SONY GROUP CORPORATION, Tokyo (JP)
Filed by SONY GROUP CORPORATION, Tokyo (JP)
Filed on May 30, 2024, as Appl. No. 18/678,656.
Application 18/678,656 is a continuation of application No. 17/255,353, granted, now 12,006,438, previously published as PCT/US2019/039582, filed on Jun. 27, 2019.
Claims priority of provisional application 62/690,656, filed on Jun. 27, 2018.
Prior Publication US 2024/0318004 A1, Sep. 26, 2024
Int. Cl. C09B 69/00 (2006.01); C07H 21/04 (2006.01); C09B 69/10 (2006.01); G01N 33/58 (2006.01)
CPC C09B 69/102 (2013.01) [C07H 21/04 (2013.01); C09B 69/109 (2013.01); G01N 33/582 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A compound having the following structure (Ia):

OG Complex Work Unit Chemistry
or a stereoisomer, salt or tautomer thereof, wherein:
M1 is, at each occurrence, independently a moiety comprising an active drug moiety;
L1a is, at each occurrence, independently a heteroarylene linker;
L1b, L2, and L3 are, at each occurrence, independently optional alkylene, alkenylene, alkynylene, heteroalkylene, heteroalkenylene or heteroalkynylene linkers;
L4 is, at each occurrence, independently an alkylene, alkenylene, alkynylene, heteroalkylene, heteroalkenylene or heteroalkynylene linker;
R1 and R2 are each independently H, OH, SH, alkyl, alkoxy, alkylether, heteroalkyl, —OP(═Ra)(Rb)Rc, Q, or L′;
R4 is, at each occurrence, independently OH, SH, O−, S−, ORd or SRd;
R5 is, at each occurrence, independently oxo, thioxo or absent;
Ra is O or S;
Rb is OH, SH, O−, S−, ORd or SRd;
Rc is OH, SH, O−, S−, ORd, OL′, SRd, alkyl, alkoxy, heteroalkyl, heteroalkoxy, alkylether, alkoxyalkylether, phosphate, thiophosphate, phosphoalkyl, thiophosphoalkyl, phosphoalkylether or thiophosphoalkylether;
Rd is a counter ion;
Q is, at each occurrence, independently a moiety comprising a sulfhydryl, disulfide, activated ester, isothiocyanate, azide, alkyne, alkene, diene, dienophile, acid halide, sulfonyl halide, phosphine, α-haloamide, biotin, amino or maleimide functional group;
L′ is, at each occurrence, independently comprises an alkylene or heteroalkylene linker covalently bonded to: Q, a targeting moiety selected from an antibody and a cell surface receptor antagonist, a solid support selected from a polymeric bead and a non-polymeric bead, or a nucleoside;
m is, at each occurrence, an integer of one or greater; and
n is an integer of one or greater.