US 12,391,767 B2
Antibodies to symmetrically dimethylated arginine analytes and use thereof
Johnny Valdez, Fremont, CA (US); Byung Sook Moon, Palo Alto, CA (US); Ki Chung, Fremont, CA (US); and Yunfei Chen, Fremont, CA (US)
Assigned to Ark Diagnostics, Inc., Fremont, CA (US)
Filed by Ark Diagnostics, Inc., Fremont, CA (US)
Filed on Sep. 16, 2022, as Appl. No. 17/946,908.
Application 17/946,908 is a division of application No. 17/476,261, filed on Sep. 15, 2021, granted, now 11,459,403.
Application 17/476,261 is a division of application No. 16/988,418, filed on Aug. 7, 2020, granted, now 11,149,093, issued on Oct. 19, 2021.
Application 16/988,418 is a division of application No. 16/907,932, filed on Jun. 22, 2020, granted, now 10,919,982, issued on Feb. 16, 2021.
Application 16/907,932 is a division of application No. 16/723,897, filed on Dec. 20, 2019, granted, now 10,717,787, issued on Jul. 21, 2020.
Application 16/723,897 is a division of application No. 16/414,553, filed on May 16, 2019, granted, now 10,745,492, issued on Aug. 18, 2020.
Claims priority of provisional application 62/828,769, filed on Apr. 3, 2019.
Prior Publication US 2023/0151119 A1, May 18, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07C 279/14 (2006.01); A61K 9/19 (2006.01); C07K 16/44 (2006.01); G01N 33/535 (2006.01); G01N 33/563 (2006.01)
CPC C07K 16/44 (2013.01) [A61K 9/19 (2013.01); C07C 279/14 (2013.01); G01N 33/535 (2013.01); G01N 33/563 (2013.01); C07K 2317/14 (2013.01); C07K 2317/20 (2013.01); C07K 2317/34 (2013.01); C07K 2317/565 (2013.01); C12Y 101/01049 (2013.01)] 18 Claims
 
1. A compound of Formula 1:

OG Complex Work Unit Chemistry
wherein:
R1 is —Y—Z;
Y is a linking group; and
Z is a label enzyme selected from the group consisting of an alkaline phosphatase, a β-galactosidase, and a horseradish peroxidase.