	US 12,391,766 B2
	Antibodies against N-acetylglucosamine and N-acetyl-galactosamine
Huiru Wang, Beijing (CN)
Assigned to B&H BIOTECHNOLOGIES, LLC, Willowbrook, IL (US)
Filed by B & H Biotechnologies, LLC, Willowbrook, IL (US)
Filed on Aug. 12, 2022, as Appl. No. 17/819,545.
Application 17/819,545 is a continuation of application No. 15/999,337, granted, now 11,446,328, previously published as PCT/CN2017/073890, filed on Feb. 17, 2017.
Claims priority of application No. PCT/CN2016/074146 (WO), filed on Feb. 19, 2016.
Prior Publication US 2023/0065536 A1, Mar. 2, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/395 (2006.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/42 (2025.01); A61P 1/18 (2006.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C07K 16/30 (2006.01); C07K 16/44 (2006.01); C12N 15/62 (2006.01); G01N 33/574 (2006.01); G01N 33/68 (2006.01); A61K 39/00 (2006.01)

CPC C07K 16/30 (2013.01) [A61K 39/395 (2013.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/42 (2025.01); A61P 1/18 (2018.01); A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C07K 14/70517 (2013.01); C07K 14/70521 (2013.01); C07K 16/44 (2013.01); C12N 15/62 (2013.01); G01N 33/574 (2013.01); G01N 33/57484 (2013.01); G01N 33/6893 (2013.01); A61K 2039/505 (2013.01); C07K 2317/76 (2013.01); C07K 2319/00 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01)]

16 Claims

1. A method for treating rheumatoid arthritis in an individual comprising administering to the individual an effective amount of an antibody that specifically binds to an epitope comprising N-acetylglucosamine or N-acetyl-galactosamine; wherein the antibody comprises a light chain variable region comprising an HVR-L1 sequence of SEQ ID NO: 5, an HVR-L2 sequence of FTSX₁LX₂S (SEQ ID NO: 25), and an HVR-L3 sequence of SEQ ID NO: 9, wherein X₁is T or S and X₂is Q or E, and wherein the antibody comprises a heavy chain variable region comprising an HVR-H1 sequence of SEQ ID NO: 1, an HVR-H2 sequence of SEQ ID NO: 2, and an HVR-H3 sequence of SEQ ID NO: 3.