US 12,391,742 B2
Anti-KRAS-G12D T cell receptors
Eric Tran, Portland, OR (US); Yong-Chen Lu, Little Rock, AR (US); Anna Pasetto, Asker (NO); Paul F. Robbins, Chevy Chase, MD (US); Steven A. Rosenberg, Potomac, MD (US); and Zhili Zheng, Gaithersburg, MD (US)
Assigned to The United States of America, as represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US)
Filed by The United States of America, as represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US)
Filed on Jan. 25, 2024, as Appl. No. 18/423,020.
Application 16/838,395 is a division of application No. 16/321,899, granted, now 10,611,816, issued on Apr. 7, 2020, previously published as PCT/US2017/044615, filed on Jul. 31, 2017.
Application 18/423,020 is a continuation of application No. 17/345,390, filed on Jun. 11, 2021, granted, now 11,897,933.
Application 17/345,390 is a continuation of application No. 16/838,395, filed on Apr. 2, 2020, granted, now 11,208,456, issued on Dec. 28, 2021.
Claims priority of provisional application 62/369,883, filed on Aug. 2, 2016.
Prior Publication US 2024/0209059 A1, Jun. 27, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 14/725 (2006.01); A61K 38/00 (2006.01); A61P 35/00 (2006.01); C07K 14/82 (2006.01); C12N 15/85 (2006.01); G01N 33/574 (2006.01)
CPC C07K 14/7051 (2013.01) [A61P 35/00 (2018.01); C07K 14/82 (2013.01); C12N 15/85 (2013.01); G01N 33/57407 (2013.01); A61K 38/00 (2013.01); C12N 2015/8518 (2013.01); G01N 2333/7051 (2013.01)] 20 Claims
 
1. A recombinant expression vector comprising a nucleic acid comprising a nucleotide sequence encoding a polypeptide, wherein the polypeptide comprises the amino acid sequences of:
(a) SEQ ID NOs: 9-14;
(b) SEQ ID NOs: 17-22;
(c) SEQ ID NOs: 25-30; or
(d) SEQ ID NOs: 33-38.