US 12,391,732 B2
Articles comprising a silk polypeptide for antigen delivery
Lin Romer, Munich (DE); Ute Slotta, Munich (DE); Julia Engert, Munich (DE); Gerhard Winter, Penzberg (DE); Matthias Lucke, Munich (DE); and Thomas Scheibel, Bayreuth (DE)
Assigned to AMSILK GmbH, Planegg/Martinsried (DE); Ludwig-Maximilians-Universitat Munchen, Munich (DE); and Universitat Bayreuth, Bayreuth (DE)
Filed by AMSILK GmbH, Planegg/Martinsried (DE); Ludwig-Maximilians-Universitat Munchen, Munich (DE); and Universitat Bayreuth, Bayreuth (DE)
Filed on Nov. 1, 2023, as Appl. No. 18/499,938.
Application 18/499,938 is a division of application No. 17/383,926, filed on Jul. 23, 2021, granted, now 11,827,678.
Application 17/383,926 is a division of application No. 16/307,622, granted, now 11,104,708, previously published as PCT/EP2017/064436, filed on Jun. 13, 2017.
Claims priority of application No. 16175724 (EP), filed on Jun. 22, 2016.
Prior Publication US 2024/0287146 A1, Aug. 29, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 14/00 (2006.01); A61K 39/385 (2006.01); A61K 47/42 (2017.01); A61K 47/64 (2017.01); A61K 47/65 (2017.01); A61P 35/00 (2006.01); C07K 14/435 (2006.01); C12N 15/62 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01)
CPC C07K 14/43518 (2013.01) [A61K 39/385 (2013.01); A61K 47/42 (2013.01); A61K 47/646 (2017.08); A61K 47/65 (2017.08); A61P 35/00 (2018.01); C07K 14/43586 (2013.01); C12N 15/62 (2013.01); A61K 38/00 (2013.01); A61K 2039/6031 (2013.01); A61K 2039/627 (2013.01); C07K 2319/40 (2013.01); C07K 2319/50 (2013.01)] 8 Claims
 
1. A particle having an average diameter of no more than 500 nm, comprising a polypeptide, said polypeptide comprising
(i) a silk polypeptide,
(ii) an antigen, and
(iii) an enzymatically cleavable linker,
wherein the antigen is connected to the silk polypeptide via the enzymatically cleavable linker.