US 12,391,717 B2
Method for preparing sucrose-6-ester
Weiqiang Jiang, Anhui (CN); Jiaxin Xia, Anhui (CN); Zhengsong Zhang, Anhui (CN); Zhijian Yang, Anhui (CN); and Chaohui Chen, Anhui (CN)
Assigned to ANHUI JINHE INDUSTRIAL CO., LTD., Anhui (CN)
Appl. No. 18/003,504
Filed by ANHUI JINHE INDUSTRIAL CO., LTD., Anhui (CN)
PCT Filed Sep. 10, 2020, PCT No. PCT/CN2020/114505
§ 371(c)(1), (2) Date Dec. 28, 2022,
PCT Pub. No. WO2022/051988, PCT Pub. Date Mar. 17, 2022.
Prior Publication US 2023/0295210 A1, Sep. 21, 2023
Int. Cl. C07H 13/04 (2006.01); C07H 1/00 (2006.01)
CPC C07H 13/04 (2013.01) [C07H 1/00 (2013.01)] 16 Claims
 
1. A method for preparing a sucrose-6-ester, comprising:
preparing a reaction solution, comprising heating and dissolving sucrose and an organo-tin compound in a polar aprotic solvent, and adding a non-polar solvent thereto to obtain a reaction solution;
atomizing, comprising atomizing the reaction solution to form droplets;
dehydrating, comprising thoroughly mixing and contacting the droplets with a gasified dehydration medium such that the droplets undergo a dehydration reaction to obtain an intermediate mixture containing sucrose organic tin ester droplets;
separating, comprising separating the intermediate mixture to obtain a sucrose organic tin ester solution and a dehydrated gas-liquid mixture;
circulating, comprising recovering the sucrose organic tin ester solution obtained in the separating step and cycling to the atomizing and dehydrating steps several times; and
acylating, comprising subjecting an organic acid anhydride to an acylation reaction with the sucrose organic tin ester solution to obtain the sucrose-6-ester.