US 12,391,707 B2
Preparation method for oxazepine compound
Yanbin Hu, Shanghai (CN); Fei Sun, Shanghai (CN); and Charles Z. Ding, Shanghai (CN)
Assigned to FUJIAN AKEYLINK BIOTECHNOLOGY CO., LTD., Ningde (CN)
Appl. No. 17/635,462
Filed by FUJIAN AKEYLINK BIOTECHNOLOGY CO., LTD., Ningde (CN)
PCT Filed Jul. 28, 2020, PCT No. PCT/CN2020/105248
§ 371(c)(1), (2) Date Feb. 15, 2022,
PCT Pub. No. WO2021/027566, PCT Pub. Date Feb. 18, 2021.
Claims priority of application No. 201910754972.2 (CN), filed on Aug. 15, 2019.
Prior Publication US 2022/0306648 A1, Sep. 29, 2022
Int. Cl. C07D 498/04 (2006.01)
CPC C07D 498/04 (2013.01) 17 Claims
 
1. A preparation method for a compound of formula (I),

OG Complex Work Unit Chemistry
comprising the following steps:

OG Complex Work Unit Chemistry
wherein,
W is selected from OH, C1-6 alkoxy and C1-6 alkylamino;
R1 is selected from C1-6 alkyl;
R2 is selected from H, F, Cl, Br, I, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylamino, —C(═O)—C1-6 alkyl, C3-6 cycloalkyl and 3-6 membered heterocycloalkyl, wherein the C1-6 alkyl, C1-6 alkoxy, C1-6 alkylamino, C3-6 cycloalkyl and 3-6 membered heterocycloalkyl are optionally substituted with 1, 2 or 3 Ra;
R3 is selected from

OG Complex Work Unit Chemistry
R is selected from OH, CN, NH2, C1-6 alkoxy, C1-6 alkylamino, C1-6 alkylthio, —C(═O)—C1-6 alkyl, —C(═O)—C1-6 alkylamino, —O—C(═O)—C1-6 alkylamino, —NH—C(═O)—C1-6 alkoxy, C2-5 alkenyl, C2-5 heteroalkenyl, C3-6 cycloalkyl and 3-6 membered heterocycloalkyl, wherein the C1-6 alkyl, C1-6 alkoxy, C1-6 alkylamino, C1-6 alkylthio, —C(═O)—C1-6 alkyl, —C(═O)—C1-6 alkylamino, —O—C(═O)—C1-6 alkylamino, —NH—C(═O)—C1-6 alkoxy, C2-5 alkenyl, C2-5 heteroalkenyl, C3-6 cycloalkyl and 3-6 membered heterocycloalkyl are optionally substituted with 1, 2 or 3 Rb;
m is selected from 0, 1, 2, 3, 4 and 5;
Ra and Rb are each independently selected from COOH, F, Cl, Br, I, OH, CN, NH2, CH3, CH2CH3, CH2CH2CH3, OCH3, —NHCH3, —N(CH3)2 and CF3.
 
13. A preparation method for compound 13,

OG Complex Work Unit Chemistry
comprising the following steps:

OG Complex Work Unit Chemistry