US 12,391,701 B2
Chromene-based compounds, methods and uses thereof
Marta Sílvia Freitas Da Costa, Sáo Mamede Este (PT); Maria De Fátima Monginho Baltazar, Lago (PT); Maria Fernanda De Jesus Rego Paiva Proença, Braga (PT); Patrícia Maciel, Oporto (PT); and Olívia Alexandra Elias Pontes, Morais (PT)
Assigned to UNIVERSITY OF MINHO, Braga (PT)
Appl. No. 17/560,859
Filed by University of Minho, Braga (PT)
PCT Filed Jun. 29, 2020, PCT No. PCT/IB2020/056131
§ 371(c)(1), (2) Date Dec. 23, 2021,
PCT Pub. No. WO2020/261242, PCT Pub. Date Dec. 30, 2020.
Claims priority of application No. 115617 (PT), filed on Jun. 28, 2019; application No. 20166501 (EP), filed on Mar. 27, 2020; and application No. PCT/EP2020/059156 (WO), filed on Mar. 31, 2020.
Prior Publication US 2024/0092793 A1, Mar. 21, 2024
Int. Cl. C07D 491/052 (2006.01); A61K 31/4188 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); C07D 519/00 (2006.01)
CPC C07D 491/052 (2013.01) [C07D 519/00 (2013.01)] 11 Claims
 
1. A compound having the structure:

OG Complex Work Unit Chemistry
wherein
R1 is substituted aryl, or substituted phenyl;
R2 is H, alkyl, alkoxyl, halogen, hydroxyl, or amine;
R3 is H or

OG Complex Work Unit Chemistry
with the proviso that

OG Complex Work Unit Chemistry
 are excluded,
or a pharmaceutically acceptable salt, N-oxide, stereoisomer, diastereoisomer, enantiomer or atropisomer.