US 12,391,696 B2
Pyrrolopyrazole derivatives, preparation method thereof and application thereof in medicine
Feng Ren, Shanghai (CN); Xianlian Wang, Shanghai (CN); Yongmei Xu, Shanghai (CN); Chunlin Chen, Shanghai (CN); and Jinna Cai, Shanghai (CN)
Assigned to SHANGHAI MEDICILON INC., Shanghai (CN); and MEDICILON PRECLINICAL RESEARCH (SHANGHAI) LLC., Shanghai (CN)
Appl. No. 17/630,110
Filed by SHANGHAI MEDICILON INC., Shanghai (CN); and MEDICILON PRECLINICAL RESEARCH (SHANGHAI) LLC., Shanghai (CN)
PCT Filed Aug. 26, 2019, PCT No. PCT/CN2019/102525
§ 371(c)(1), (2) Date Jan. 25, 2022,
PCT Pub. No. WO2021/017067, PCT Pub. Date Feb. 4, 2021.
Claims priority of application No. 201910683538.X (CN), filed on Jul. 26, 2019.
Prior Publication US 2022/0281877 A1, Sep. 8, 2022
Int. Cl. C07D 487/04 (2006.01); A61P 1/04 (2006.01)
CPC C07D 487/04 (2013.01) [A61P 1/04 (2018.01)] 2 Claims
 
1. A compound represented by general formula (I) or a pharmaceutically acceptable salt thereof,

OG Complex Work Unit Chemistry
wherein:
R1 is selected from hydrogen atom, chlorine, bromine, iodine or C1-5 alkyl;
R2 is selected from halogen, hydroxyl or C1-5 alkyl;
n=1 or 2;
R3 is connected to a carbon atom, X is CH2, R3 is selected from NRbRc, and Rb and Rc are linked together and form a six-membered heterocyclic ring with the N to which they are linked.