US 12,391,682 B2
Isoquinoline derivatives and their use for the treatment of parasitic infections
Bernd Alig, Koenigswinter (DE); Walter Huebsch, Wuppertal (DE); Nils Griebenow, Dormagen (DE); Hans-Georg Schwarz, Dorsten (DE); Wei Zhuang, Monheim am Rhein (DE); Daniel Kulke, Leverkusen (DE); Claudia Boehm, Hannover (DE); Iring Heisler, Duesseldorf (DE); Isa Jana Irina Janssen, Wiesbaden (DE); and Kirsten Boerngen, Cologne (DE)
Assigned to Elanco Animal Health GmbH, Monheim am Rhein (DE)
Appl. No. 17/630,742
Filed by Elanco Animal Health GmbH, Monheim am Rhein (DE)
PCT Filed Jul. 27, 2020, PCT No. PCT/EP2020/071139
§ 371(c)(1), (2) Date Jan. 27, 2022,
PCT Pub. No. WO2021/018839, PCT Pub. Date Feb. 4, 2021.
Claims priority of application No. 19189099 (EP), filed on Jul. 30, 2019.
Prior Publication US 2022/0274971 A1, Sep. 1, 2022
Int. Cl. C07D 413/14 (2006.01); C07D 405/12 (2006.01)
CPC C07D 413/14 (2013.01) [C07D 405/12 (2013.01)] 15 Claims
 
1. A compound of formula (I):

OG Complex Work Unit Chemistry
in which:
A is A1 or A2,

OG Complex Work Unit Chemistry
o is 0, 1, 2, 3 or 4,
R is selected from the group consisting of hydrogen, halogen, cyano, nitro, OH, C1-C4-alkyl, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C1-C4-alkoxy, C1-C4-halogenoalkoxy having 1 to 5 halogen atoms, C3-C6-cycloalkyl, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —S—C1-C4-alkyl, —S(O)—C1-C4-alkyl, —SO2-C1-C4-alkyl, —S—C1-C4-halogenoalkyl, —S(O)—C1-C4-halogenoalkyl and —SO2—C1-C4-halogenoalkyl having 1 to 5 halogen atoms,
Rp is selected from the group consisting of hydrogen and C1-C4-alkyl,
X, Y are independently selected from the group consisting of C7R8, O, S, and N-R9, wherein at least one of X and Y is CR7R8, or
X, Y form together a ring member selected from the group consisting of —C(O)—O—, —C(O)—NR9—, —S(O)—NR9—, —SO2—NR9— and —SO2—O—,
R1 is selected from the group consisting of hydrogen, cyano, —CHO, —OH, C1-C4-alkyl, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C1-C4-alkoxy, C1-C4-halogenoalkoxy having 1 to 5 halogen atoms, C3-C6-cycloalkyl, C3-C6-halogenocycloalkyl having 1 to 5 halogen atoms, C3-C4-alkenyl, C3-C4-alkynyl, C1-C4-alkoxy-C1-C4-alkyl, C3-C6-cycloalkyl-C1-C3-alkyl, cyano-C1-C4-alkyl, —NH—C1-C4-alkyl, —N(C1-C4-alkyl)2, NH2-C1-C4-alkyl-, C1-C4-alkyl-NH—C1-C4-alkyl-, (C1-C4-alkyl)2N—C1-C4-alkyl-, C1-C4-alkyl-C(O)—, C1-C4-halogenoalkyl-C(O)— having 1 to 5 halogen atoms, C1-C4-alkoxy-C(O)—, benzyloxy-C(O)—, C1-C4-alkoxy-C1-C4-alkyl-C(O)—, —SO2—C1-C4-alkyl, and —SO2—C1-C4-halogenoalkyl having 1 to 5 halogen atoms;
phenyl-C1-C4-alkyl, optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of halogen, —OH, —NO2, cyano, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C1-C4-alkoxy, C1-C4-halogenoalkoxy having 1 to 5 halogen atoms, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —S—C1-C4-alkyl, —S(O)—C1-C4-alkyl, —SO2—C1-C4-alkyl, —S—C1-C4-halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C1-C4-halogenoalkyl having 1 to 5 halogen atoms and —SO2—C1-C4-halogenoalkyl having 1 to 5 halogen atoms; and
heterocyclyl-C1-C4-alkyl, wherein the heterocyclyl substituent of the heterocyclyl-C1-C4-alkyl is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, —OH, —NO2, cyano, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C1-C4-alkoxy, C1-C4-halogenoalkoxy having 1 to 5 halogen atoms, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —S—C1-C4-alkyl, —S(O)—C1-C4-alkyl, —SO2—C1-C4-alkyl, —S—C1-C4-halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C1-C4-halogenoalkyl having 1 to 5 halogen atoms and —SO2—C1-C4-halogenoalkyl having 1 to 5 halogen atoms,
R2 is selected from the group consisting of
hydrogen, halogen, cyano, —COOH, C1-C4-alkoxy-C(O)—, —C(O)—NH2, —C(O)—NH(C1-C4-alkyl), —C(O)—N(C1-C4-alkyl)2;
—NR12R13;
—OR14;
—SR15, —S(O)R15, —SO2R15;
C1-C6-alkyl, C3-C6-cycloalkyl, C2-C4-alkenyl, C3-C6-cycloalkenyl, C2-C4-alkynyl, phenyl-C1-C4-alkyl, each of which is optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of halogen, —OH, —NO2, cyano, C1-C4-alkyl-C(O)—, C1-C4-alkoxy-C(O)—, —C(O)—NH2, —C(O)—NH(C1-C4-alkyl), —C(O)—N(C1-C4-alkyl)2, C1-C4-alkyl, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C1-C4-alkoxy, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —NH(C(O)—C1-C4-alkyl), —N(C1-C4-alkyl)(C(O)—C1-C4-alkyl), —S—C1-C4-alkyl, —S(O)—C1-C4-alkyl, —SO2—C1-C4-alkyl, —S—C1-C4-halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C1-C4-halogenoalkyl having 1 to 5 halogen atoms and —SO2—C1-C4-halogenoalkyl having 1 to 5 halogen atoms;
heterocyclyl-C1-C4-alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, —OH, —NO2, cyano, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C1-C4-alkoxy, C1-C4-halogenoalkoxy having 1 to 5 halogen atoms, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —S—C1-C4-alkyl, —S(O)—C1-C4-alkyl, —SO2—C1-C4-alkyl, —S—C1-C4-halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C1-C4-halogenoalkyl having 1 to 5 halogen atoms and —SO2—C1-C4-halogenoalkyl having 1 to 5 halogen atoms;
phenyl which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, C1-C4-alkyl, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C1-C4-alkoxy, C1-C4-halogenoalkoxy having 1 to 5 halogen atoms, C3-C6-cycloalkyl, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —S—C1-C4-alkyl, —S(O)—C1-C4-alkyl, —SO2-C1-C4-alkyl, —S—C1-C4-halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C1-C4-halogenoalkyl having 1 to 5 halogen atoms and —SO2—C1-C4-halogenoalkyl having 1 to 5 halogen atoms; and
a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, heterospirocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2, 3 or 4 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, oxo, thiono, —COOH, C1-C4-alkoxy-C(O)—, —C(O)—NH2, —C(O)—NH(C1-C4-alkyl), —C(O)—N(C1-C4-alkyl)2, C1-C4-alkyl, C1-C4-alkyl-C(O)—, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C1-C4-alkoxy, hydroxy-C1-C4-alkyl, C1-C4-alkoxy-C1-C4-alkyl-, C1-C4-halogenoalkoxy having 1 to 5 halogen atoms, C3-C6-cycloalkyl, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —S—C1-C4-alkyl, —S(O)—C1-C4-alkyl, —SO2—C1-C4-alkyl, —S—C1-C4-halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C1-C4-halogenoalkyl having 1 to 5 halogen atoms, —SO2—C1-C4-halogenoalkyl having 1 to 5 halogen atoms, and 4- to 10-membered heterocycloalkyl,
R3 is hydrogen or C1-C4-alkyl,
R4 is selected from the group consisting of hydrogen, halogen, —OH, cyano, C1-C4-alkyl, C3-C6-cycloalkyl, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C1-C4-alkoxy-C1-C4-alkyl, C1-C4-alkoxy, C1-C4-halogenoalkoxy having 1 to 5 halogen atoms, C1-C4-alkyl-C(O)—, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —S—C1-C4-alkyl, —S(O)—C1-C4-alkyl, and —SO2—C1-C4-alkyl,
R5 is selected from the group consisting of hydrogen, halogen, —OH, cyano, C1-C4-alkyl, C3-C6-cycloalkyl, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C1-C4-alkoxy-C1-C4-alkyl, C1-C4-alkoxy, C1-C4-halogenoalkoxy having 1 to 5 halogen atoms, C1-C4-alkyl-C(O)—, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —S—C1-C4-alkyl, —S(O)—C1-C4-alkyl, and —SO2—C1-C4-alkyl,
R6 is selected from the group consisting of hydrogen, halogen, —OH, cyano, C1-C4-alkyl, C3-C6-cycloalkyl, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C1-C4-alkoxy-C1-C4-alkyl, C1-C4-alkoxy, C1-C4-halogenoalkoxy having 1 to 5 halogen atoms, C1-C4-alkyl-C(O)—, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —S—C1-C4-alkyl, —S(O)—C1-C4-alkyl, and —SO2—C1-C4-alkyl,
R7 is selected from the group consisting of hydrogen, —OH, fluorine, C1-C4-alkyl and C1-C4-alkoxy,
R8 is selected from the group consisting of hydrogen, —OH, fluorine, C1-C4-alkyl and C1-C4-alkoxy,
or R7 and R8 together form an oxo group (═O),
or R7 and R8 form, together with the carbon atom to which they are attached, a 3- to 6-membered ring selected from the group consisting of C3-C6-cycloalkyl and 3- to 6-membered heterocycloalkyl,
R9 is selected from the group consisting of hydrogen, C1-C4-alkyl, C1-C4-halogenoalkyl having 1 to 5 halogen atoms and C1-C4-alkoxy,
R10 is selected from the group consisting of hydrogen, —OH, C1-C4-alkyl and C1-C4-alkoxy,
R11 is selected from the group consisting of hydrogen, C1-C4-alkyl and C1-C4-alkoxy,
or R10 and R11 form, together with the carbon atom to which they are attached, a 3- to 6-membered ring selected from the group consisting of C3-C6-cycloalkyl and 3- to 6-membered heterocycloalkyl,
R12 and R13 are independently selected from the group consisting of
hydrogen, —OH, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —NH(—C(O)—C1-C4-alkyl), —N(C1-C4-alkyl)(-C(O)—C1-C4-alkyl), C1-C4-alkoxy, C1-C4-alkoxy-C(O)—;
C3-C6-cycloalkyl, phenyl-C1-C4-alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, —OH, cyano, —COOH, C1-C4-alkoxy-C(O)—, —C(O)—NH2, —C(O)—NH(C1-C4-alkyl), —C(O)—N(C1-C4-alkyl)2, —NH—C(O)—C1-C4-alkyl, —N(C1-C4-alkyl)(-C(O)—C1-C4-alkyl), C1-C4-alkyl, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C1-C4-alkoxy, C1-C4-halogenoalkoxy having 1 to 5 halogen atoms, C3-C6-cycloalkyl, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —S—C1-C4-alkyl, —S(O)—C1-C4-alkyl, —SO2—C1-C4-alkyl, —S—C1-C4-halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C1-C4-halogenoalkyl having 1 to 5 halogen atoms, —SO2—C1-C4-halogenoalkyl having 1 to 5 halogen atoms and (C1-C4-alkoxy)2P(═O)—;
heterocyclyl-C1-C4-alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, oxo, thiono, —COOH, C1-C4-alkoxy-C(O)—, —C(O)—NH2, —C(O)—NH(C1-C4-alkyl), —C(O)—N(C1-C4-alkyl)2, C1-C4-alkyl, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C1-C4-alkoxy, hydroxy-C1-C4-alkyl, C1-C4-halogenoalkoxy having 1 to 5 halogen atoms, C3-C6-cycloalkyl, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —S—C1-C4-alkyl, —S(O)—C1-C4-alkyl, —SO2—C1-C4-alkyl, —S—C1-C4-halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C1-C4-halogenoalkyl having 1 to 5 halogen atoms and —SO2—C1-C4-halogenoalkyl having 1 to 5 halogen atoms;
phenyl, benzo-C5-C6-cycloalkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, C1-C4-alkyl, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C1-C4-alkoxy, C1-C4-halogenoalkoxy having 1 to 5 halogen atoms, C3-C6-cycloalkyl, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —S—C1-C4-alkyl, —S(O)—C1-C4-alkyl, —SO2—C1-C4-alkyl, —S—C1-C4-halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C1-C4-halogenoalkyl having 1 to 5 halogen atoms and —SO2—C1-C4-halogenoalkyl having 1 to 5 halogen atoms; and
a monocyclic or a bicyclic heterocycle selected from the group of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, oxo, thiono, —COOH, C1-C4-alkoxy-C(O)—, —C(O)—NH2, —C(O)—NH(C1-C4-alkyl), —C(O)—N(C1-C4-alkyl)2, C1-C4-alkyl, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C1-C4-alkoxy, hydroxy-C1-C4-alkyl, C1-C4-halogenoalkoxy having 1 to 5 halogen atoms, C3-C6-cycloalkyl, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —S—C1-C4-alkyl, —S(O)—C1-C4-alkyl, —SO2-C1-C4-alkyl, —S—C1-C4-halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C1-C4-halogenoalkyl having 1 to 5 halogen atoms and —SO2—C1-C4-halogenoalkyl having 1 to 5 halogen atoms,
R14 is selected from the group consisting of
—NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2;
C1-C4-alkyl, C3-C6-cycloalkyl, phenyl-C1-C4-alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, —OH, cyano, —COOH, C1-C4-alkoxy-C(O)—, —C(O)—NH2, —C(O)—NH(C1-C4-alkyl), —C(O)—N(C1-C4-alkyl)2, C1-C4-alkyl, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C1-C4-alkoxy, C1-C4-halogenoalkoxy having 1 to 5 halogen atoms, C3-C6-cycloalkyl, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —S—C1-C4-alkyl, —S(O)—C1-C4-alkyl, —SO2—C1-C4-alkyl, —S—C1-C4-halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C1-C4-halogenoalkyl having 1 to 5 halogen atoms and —SO2—C1-C4-halogenoalkyl having 1 to 5 halogen atoms;
heterocyclyl-C1-C4-alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, oxo, thiono, —COOH, C1-C4-alkoxy-C(O)—, —C(O)—NH2, —C(O)—NH(C1-C4-alkyl), —C(O)—N(C1-C4-alkyl)2, C1-C4-alkyl, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C1-C4-alkoxy, hydroxy-C1-C4-alkyl, C1-C4-halogenoalkoxy having 1 to 5 halogen atoms, C3-C6-cycloalkyl, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —S—C1-C4-alkyl, —S(O)—C1-C4-alkyl, —SO2—C1-C4-alkyl, —S—C1-C4-halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C1-C4-halogenoalkyl having 1 to 5 halogen atoms and —SO2—C1-C4-halogenoalkyl having 1 to 5 halogen atoms;
phenyl, which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, C1-C4-alkyl, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C1-C4-alkoxy, C1-C4-halogenoalkoxy having 1 to 5 halogen atoms, C3-C6-cycloalkyl, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —S—C1-C4-alkyl, —S(O)—C1-C4-alkyl, —SO2-C1-C4-alkyl, —S—C1-C4-halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C1-C4-halogenoalkyl having 1 to 5 halogen atoms and —SO2—C1-C4-halogenoalkyl having 1 to 5 halogen atoms; and
a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, oxo, thiono, —COOH, C1-C4-alkoxy-C(O)—, —C(O)—NH2, —C(O)—NH(C1-C4-alkyl), —C(O)—N(C1-C4-alkyl)2, C1-C4-alkyl, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C1-C4-alkoxy, hydroxy-C1-C4-alkyl, C1-C4-halogenoalkoxy having 1 to 5 halogen atoms, C3-C6-cycloalkyl, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —S—C1-C4-alkyl, —S(O)—C1-C4-alkyl, —SO2-C1-C4-alkyl, —S—C1-C4-halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C1-C4-halogenoalkyl having 1 to 5 halogen atoms and —SO2—C1-C4-halogenoalkyl having 1 to 5 halogen atoms,
R15 is selected from the group consisting of
hydrogen;
C1-C4-alkyl, C3-C6-cycloalkyl, phenyl-C1-C4-alkyl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, —OH, cyano, —COOH, C1-C4-alkoxy-C(O)—, —C(O)—NH2, —C(O)—NH(C1-C4-alkyl), —C(O)—N(C1-C4-alkyl)2, C1-C4-alkyl, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C1-C4-alkoxy, C1-C4-halogenoalkoxy having 1 to 5 halogen atoms, C3-C6-cycloalkyl, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —S—C1-C4-alkyl, —S(O)—C1-C4-alkyl, —SO2—C1-C4-alkyl, —S—C1-C4-halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C1-C4-halogenoalkyl having 1 to 5 halogen atoms and —SO2—C1-C4-halogenoalkyl having 1 to 5 halogen atoms;
heterocyclyl-C1-C4-alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, oxo, thiono, —COOH, C1-C4-alkoxy-C(O)—, —C(O)—NH2, —C(O)—NH(C1-C4-alkyl), —C(O)—N(C1-C4-alkyl)2, C1-C4-alkyl, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C1-C4-alkoxy, hydroxy-C1-C4-alkyl, C1-C4-halogenoalkoxy having 1 to 5 halogen atoms, C3-C6-cycloalkyl, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —S—C1-C4-alkyl, —S(O)—C1-C4-alkyl, —SO2—C1-C4-alkyl, —S—C1-C4-halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C1-C4-halogenoalkyl having 1 to 5 halogen atoms and —SO2—C1-C4-halogenoalkyl having 1 to 5 halogen atoms;
phenyl, which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, C1-C4-alkyl, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C1-C4-alkoxy, C1-C4-halogenoalkoxy having 1 to 5 halogen atoms, C3-C6-cycloalkyl, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —S—C1-C4-alkyl, —S(O)—C1-C4-alkyl, —SO2-C1-C4-alkyl, —S—C1-C4-halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C1-C4-halogenoalkyl having 1 to 5 halogen atoms and —SO2—C1-C4-halogenoalkyl having 1 to 5 halogen atoms; and
a monocyclic or a bicyclic heterocycle selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, cyano, nitro, —OH, oxo, thiono, —COOH, C1-C4-alkoxy-C(O)—, —C(O)—NH2, —C(O)—NH(C1-C4-alkyl), —C(O)—N(C1-C4-alkyl)2, C1-C4-alkyl, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, C1-C4-alkoxy, hydroxy-C1-C4-alkyl, C1-C4-halogenoalkoxy having 1 to 5 halogen atoms, C3-C6-cycloalkyl, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —S—C1-C4-alkyl, —S(O)—C1-C4-alkyl, —SO2-C1-C4-alkyl, —S—C1-C4-halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C1-C4-halogenoalkyl having 1 to 5 halogen atoms and —SO2—C1-C4-halogenoalkyl having 1 to 5 halogen atoms,
Q is selected from the group consisting of 6- or 10-membered aryl and 5- to 10-membered heteroaryl, each of which is optionally substituted by 1, 2, 3, 4 or 5 substituents selected from the group consisting of halogen, SF5, cyano, —CHO, nitro, oxo, C1-C4-alkyl, C1-C4-hydroxyalkyl, C1-C4-halogenoalkyl having 1 to 5 halogen atoms, hydroxy, C1-C4-alkoxy, C3-C6-cycloalkyl-C1-C4-alkoxy, cyano-C1-C4-alkoxy, C1-C4-halogenoalkoxy having 1 to 5 halogen atoms, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, —NH—SO2—(C1-C4-alkyl), —N(SO2—[C1-C4-alkyl])(C1-C4-alkyl), (C1-C4-alkoxyimino)-C1-C4-alkyl, 4- to 6-membered heterocyclyl, which is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl and cyano, —CH2—O—(C1-C4-alkyl), —CH2—NH(C1-C4-alkyl), —CH2—N(C1-C4-alkyl)2, methyl substituted with a 4- to 6-membered heterocyclyl which itself is optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl and cyano, —CH2—S—(C1-C4-alkyl), —CH2—S(O)—(C1-C4-alkyl), —CH2—SO2—(C1-C4-alkyl), —S—(C1-C4-alkyl), —S(O)—(C1-C4-alkyl), —SO2—(C1-C4-alkyl), —S—(C1-C4-halogenoalkyl) having 1 to 5 halogen atoms, —S(O)—(C1-C4-halogenoalkyl) having 1 to 5 halogen atoms, —SO2—(C1-C4-halogenoalkyl) having 1 to 5 halogen atoms, —CONH(C1-C4-alkyl), —CONH(C3-C6-cycloalkyl), —NHCO(C1-C4-alkyl), —NHCO(C3-C6-cycloalkyl), —NHCO(C1-C4-halogenoalkyl) having 1 to 5 halogen atoms,
wherein when Y is O, S or N—R9, none of R7, R8, R10 and R11 is —OH or C1-C4-alkoxy, and wherein when X is O, S or N—R9, none of R7 and R8 is —OH or C1-C4-alkoxy;
or a stereoisomer, tautomer, N-oxide, hydrate, solvate, or salt thereof, or a mixture thereof.