US 12,391,658 B2
Sulfoxide and sulfone glucokinase activators and methods of use thereof
Nhut Diep, Houston, TX (US); Philippe Pitchen, Genolhac (FR); and Matthew Ronsheim, Sudbury, MA (US)
Assigned to VTV THERAPEUTICS LLC, High Point, NC (US)
Appl. No. 17/760,218
Filed by vTv Therapeutics LLC, High Point, NC (US)
PCT Filed Feb. 12, 2021, PCT No. PCT/US2021/017743
§ 371(c)(1), (2) Date Aug. 5, 2022,
PCT Pub. No. WO2021/167840, PCT Pub. Date Aug. 26, 2021.
Claims priority of provisional application 62/977,873, filed on Feb. 18, 2020.
Prior Publication US 2023/0106983 A1, Apr. 6, 2023
Int. Cl. C07D 277/54 (2006.01)
CPC C07D 277/54 (2013.01) 17 Claims
 
1. A compound of Formula (X)

OG Complex Work Unit Chemistry
wherein R1 is hydrogen, methyl, or ethyl, and n is 1 or 2, or a pharmaceutically acceptable salt thereof.