US 12,391,656 B2
Solid state forms of Tafamidis and salts thereof
Sanja Matečić Mušanić, Zagreb (HR); Valentina Travančić, Zagreb (HR); and Dubravka Pavličić, Zagreb (HR)
Assigned to ASSIA CHEMICAL INDUSTRIES LTD., Tel Aviv (IL)
Appl. No. 17/610,195
Filed by ASSIA CHEMICAL INDUSTRIES LTD., Tel Aviv (IL)
PCT Filed May 15, 2020, PCT No. PCT/US2020/033039
§ 371(c)(1), (2) Date Nov. 10, 2021,
PCT Pub. No. WO2020/232325, PCT Pub. Date Nov. 19, 2020.
Claims priority of provisional application 62/927,913, filed on Oct. 30, 2019.
Claims priority of provisional application 62/909,903, filed on Oct. 3, 2019.
Claims priority of provisional application 62/871,249, filed on Jul. 8, 2019.
Claims priority of provisional application 62/848,800, filed on May 16, 2019.
Prior Publication US 2022/0259162 A1, Aug. 18, 2022
Int. Cl. C07D 263/57 (2006.01); A61P 25/02 (2006.01)
CPC C07D 263/57 (2013.01) [A61P 25/02 (2018.01); C07B 2200/13 (2013.01)] 15 Claims
 
1. A crystalline form of tafamidis designated as form V, which is characterized by
a PXRD pattern having peaks at 6.0, 19.9, 20.6, 23.9 and 29.2 degrees 2-theta±0.2 degrees 2-theta.