US 12,391,647 B2
Benzamide compound and preparation method, use, and pharmaceutical composition thereof
Heng Xu, Beijing (CN); Xiaoguang Chen, Beijing (CN); Songwen Lin, Beijing (CN); Ming Ji, Beijing (CN); Nina Xue, Beijing (CN); Deyu Wu, Beijing (CN); and Jing Jin, Beijing (CN)
Assigned to INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES, Beijing (CN)
Filed by INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES, Beijing (CN)
Filed on Oct. 27, 2022, as Appl. No. 18/050,396.
Application 18/050,396 is a continuation of application No. 16/966,433, granted, now 11,518,744, previously published as PCT/CN2019/073942, filed on Jan. 30, 2019.
Claims priority of application No. 201810090951.0 (CN), filed on Jan. 30, 2018.
Prior Publication US 2023/0099912 A1, Mar. 30, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 213/53 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01)
CPC C07D 213/53 (2013.01) [C07D 401/12 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01)] 19 Claims
 
1. A compound represented by Formula (I), or a stereoisomer, a geometric isomer, a tautomer or a pharmaceutically acceptable salt thereof:

OG Complex Work Unit Chemistry
wherein,
R1 is selected from hydrogen, cyano, difluoromethyl, trifluoromethyl, halogen, C1-3 alkyl, C1-3 alkoxy;
R2 is selected from 6- to 10-membered aryl or 5- to 10-membered heteroaryl; wherein the 6- to 10-membered aryl or 5- to 10-membered heteroaryl is optionally substituted by (Ra)m; or the 6- to 10-membered aryl or 5- to 10-membered heteroaryl is phenyl fused to 4- to 6-membered cycloalkene or 4- to 6-membered heterocycloalkene or 5- to 6-membered heteroaryl fused to the same;
each Ra is independently selected from the following groups: cyano, difluoromethyl, trifluoromethyl, halogen, C1-3 alkyl, C3-7 cycloalkyl, C1-3 alkoxy;
m is 0, 1, 2, 3, 4 or 5;
R3, R4, R5, R6 are each independently selected from hydrogen, cyano, difluoromethyl, trifluoromethyl, halogen, C1-3 alkyl, C1-3 alkoxy.