US 12,391,643 B2
Substituted amino-thiol and amino-disulfide compounds, and uses thereof
Ranjan Dohil, San Diego, CA (US); and Carlo Ballatore, San Diego, CA (US)
Assigned to The Regents of the University of California, Oakland, CA (US)
Appl. No. 17/429,885
Filed by The Regents of the University of California, Oakland, CA (US)
PCT Filed Mar. 26, 2020, PCT No. PCT/US2020/025067
§ 371(c)(1), (2) Date Aug. 10, 2021,
PCT Pub. No. WO2020/198529, PCT Pub. Date Oct. 1, 2020.
Claims priority of provisional application 62/823,892, filed on Mar. 26, 2019.
Prior Publication US 2022/0135524 A1, May 5, 2022
Int. Cl. C07C 323/25 (2006.01); A61P 1/16 (2006.01)
CPC C07C 323/25 (2013.01) [A61P 1/16 (2018.01); C07B 2200/05 (2013.01)] 34 Claims
 
1. A compound having the structure of Formula I or Formula II:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt, solvate thereof, wherein:
R1-R12 are independently selected from H or D; wherein at least one of R1-R4 is D, and wherein at least one of R5-R12 is D,
with the proviso that the compound is not selected from the group consisting of:

OG Complex Work Unit Chemistry