US 12,390,746 B2
Simulated moving-bed type chromatographic separation method and simulated moving-bed type chromatographic separation system
Masahiro Ogino, Tokyo (JP); Kazuo Okada, Tokyo (JP); Masaki Tsuruta, Tokyo (JP); Kohei Sato, Tokyo (JP); and Toshiki Miyajima, Tokyo (JP)
Assigned to ORGANO CORPORATION, Tokyo (JP)
Appl. No. 17/924,407
Filed by ORGANO CORPORATION, Tokyo (JP)
PCT Filed May 7, 2021, PCT No. PCT/JP2021/017468
§ 371(c)(1), (2) Date Nov. 10, 2022,
PCT Pub. No. WO2021/230144, PCT Pub. Date Nov. 18, 2021.
Claims priority of application No. 2020-085028 (JP), filed on May 14, 2020.
Prior Publication US 2023/0338871 A1, Oct. 26, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. B01D 15/18 (2006.01); B01D 15/42 (2006.01)
CPC B01D 15/1828 (2013.01) [B01D 15/1842 (2013.01); B01D 15/1871 (2013.01); B01D 15/424 (2013.01)] 7 Claims
OG exemplary drawing
 
1. A simulated moving-bed type chromatographic separation method comprising separating a weakly adsorptive component, a strongly adsorptive component, and an intermediately adsorptive component that has adsorptive property intermediate between the two components, with respect to an adsorbent, with two or more kinds of eluents by using a circulation system, the weakly adsorptive component, the strongly adsorptive component, and the intermediately adsorptive component being contained in a feed solution,
wherein, in the circulation system, three or more unit packed columns each packed with an adsorbent are connected in series and in an endless form via pipes,
wherein the circulation system is divided into three sections 1 to 3 provided, in an annularly continuous manner, from an upstream side to a downstream side while each section has at least one unit packed column,
wherein a feed solution supply port F, two or more eluent supply ports D corresponding to the two or more kinds of eluents, an extraction port A of a weakly adsorptive fraction containing the weakly adsorptive component, an extraction port B of an intermediately adsorptive fraction containing the intermediately adsorptive component, and an extraction port C of a strongly adsorptive fraction containing the strongly adsorptive component are provided on the pipes of the circulation system, and positions of the feed solution supply port F, the extraction port A, the extraction port B, and the extraction port C are set as the following (a) to (c):
(a) the extraction port B is provided on the downstream side of the feed solution supply port F with at least one section interposed therebetween;
(b) the extraction port C is provided on the pipe having the feed solution supply port F or the extraction port C is provided on the upstream side of the feed solution supply port F with at least one section interposed therebetween; and
(c) the extraction port A is provided on the pipe having the extraction port B or the extraction port A is provided on the downstream side of the extraction port B with at least one section interposed therebetween, and
wherein the chromatographic separation method comprises, in sequence and a repeated manner, the following steps (A) and (B):
[step (A)]
a step of simultaneously or separately supplying the feed solution from the feed solution supply port F and the two or more kinds of eluents from the two or more eluent supply ports D, respectively, and simultaneously or separately extracting the weakly adsorptive fraction from the extraction port A, the intermediately adsorptive fraction from the extraction port B, and the strongly adsorptive fraction from the extraction port C, respectively; and
[step (B)]
a step of shifting the feed solution supply port F, the eluent supply ports D, the extraction port A, the extraction port B, and the extraction port C to the downstream side, while maintaining a relative positional relationship therebetween after finishing the step (A).