US 12,390,643 B2
High frequency epidural stimulation to control sensation
Chet T. Mortiz, Seattle, WA (US); Abed Khorasani, Seattle, WA (US); Soshi Samejima, Seattle, WA (US); and Nicholas Tolley, Seattle, WA (US)
Assigned to University of Washington, Seattle, WA (US)
Appl. No. 18/007,948
Filed by UNIVERSITY OF WASHINGTON, Seattle, WA (US); and Abed Khorasani, Seattle, WA (US)
PCT Filed Jun. 2, 2021, PCT No. PCT/US2021/035390
§ 371(c)(1), (2) Date Dec. 2, 2022,
PCT Pub. No. WO2021/247661, PCT Pub. Date Dec. 9, 2021.
Claims priority of provisional application 63/033,644, filed on Jun. 2, 2020.
Prior Publication US 2023/0271011 A1, Aug. 31, 2023
Int. Cl. A61N 1/36 (2006.01)
CPC A61N 1/36067 (2013.01) [A61N 1/36062 (2017.08); A61N 1/36103 (2013.01); A61N 1/36139 (2013.01); A61N 1/36189 (2013.01); A61N 1/36196 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method for treating a neurological impairment in a subject by controlling sensation associated with a volitional motor task by the subject, the method comprising:
detecting neural signals representative of an intended volitional movement of the subject;
generating a stimulation pattern based on decoded neural signals;
modulating an amplitude of the stimulation pattern in correspondence with the decoded neural signals;
stimulating a region of a spinal cord of the subject with an electrical stimulation pattern, wherein the region is below an injury of the spinal cord, wherein the stimulation pattern comprises pulses that are based on the decoded neural signals, wherein the pulses of the stimulation pattern are delivered at a first frequency, wherein the pulses of the stimulation pattern are modulated by a modulation pattern at a second frequency that is configured for reducing pain sensation in the subject by modulating the first frequency, and wherein the second frequency is higher than the first frequency; and
wherein the stimulation pattern is delivered via one or more electrodes configured for transmitting the stimulation pattern to the spinal cord,
wherein, when received by the spinal cord, the stimulation pattern indicates intended volitional movements of the subject.