US 12,390,625 B2
Nasal drug delivery system
Adam Gold, Mountain View, CA (US); Ashley Seehusen, Mountain View, CA (US); Jonathan Toma, Menlo Park, CA (US); and Shira Koss, Palo Alto, CA (US)
Assigned to The Board of Trustees of The Leland Stanford Junior University, Stanford, CA (US)
Filed by The Board of Trustees of The Leland Stanford Junior University, Stanford, CA (US)
Filed on Sep. 15, 2021, as Appl. No. 17/476,334.
Application 17/476,334 is a continuation of application No. PCT/US2020/023826, filed on Mar. 20, 2020.
Claims priority of provisional application 62/915,371, filed on Oct. 15, 2019.
Claims priority of provisional application 62/862,562, filed on Jun. 17, 2019.
Claims priority of provisional application 62/825,668, filed on Mar. 28, 2019.
Prior Publication US 2022/0032022 A1, Feb. 3, 2022
Int. Cl. A61M 31/00 (2006.01)
CPC A61M 31/00 (2013.01) [A61M 2202/048 (2013.01); A61M 2210/0618 (2013.01); A61M 2210/0681 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A drug delivery system for delivering a substance into a subject, comprising:
a housing for carrying the substance within;
a guide member configured for insertion at least partially into a nasal cavity of the subject, the guide member having at least one lumen defined therethrough;
a flexible member translatable through the at least one lumen of the guide member;
a curved portion defined along the flexible member which forms a loop along the curved portion and having one or more openings defined along the loop at a distal end of the curved portion, wherein the curved portion extends at a predetermined curvature relative to the flexible member when the flexible member is translated from a retracted position to a deployed position and where the loop retains its configuration between the retracted position and the deployed position; and
an alignment guide extending from the housing such that the alignment guide and guide member define an angle configured for positioning the curved portion within a predetermined position within the nasal cavity while the alignment guide and guide member remain stationary relative to one another as the flexible member is translated distally to the deployed position, wherein the guide member and flexible member are rotatable relative to the alignment guide for repositioning the curved portion.