US 12,390,569 B2
Simplified regeneration of apheresis columns
Ahmed Sheriff, Berlin (DE); Birgit Vogt, Berlin (DE); and Christopher Bock, Berlin (DE)
Assigned to Pentracor GmbH, Hennigsdorf (DE)
Appl. No. 17/266,158
Filed by Pentracor GmbH, Hennigsdorf (DE)
PCT Filed Aug. 1, 2019, PCT No. PCT/EP2019/070840
§ 371(c)(1), (2) Date Feb. 5, 2021,
PCT Pub. No. WO2020/030532, PCT Pub. Date Feb. 13, 2020.
Claims priority of application No. 18187611 (EP), filed on Aug. 6, 2018.
Prior Publication US 2021/0308352 A1, Oct. 7, 2021
Int. Cl. A61M 1/34 (2006.01); B01D 15/20 (2006.01); B01D 15/38 (2006.01)
CPC A61M 1/3496 (2013.01) [B01D 15/203 (2013.01); B01D 15/3804 (2013.01); A61M 2202/0445 (2013.01)] 14 Claims
OG exemplary drawing
 
1. An apheresis device for extracorporeal removal of CRP from blood comprising:
an extracorporeal circulation system for blood,
means for generation and regulation of a flow of blood in the extracorporeal circulation system,
a cell separator for separation of the blood into blood plasma and cellular components,
at least one apheresis column for affinity chromatographic removal of CRP from blood,
wherein the extracorporeal circulation system comprises an arterial line to the cell separator, a first plasma line from the cell separator to the apheresis column, a second plasma line for CRP-depleted blood plasma from the apheresis column to a point, a cell line for the separated cellular components from the cell separator to the point and a venous line starting from the point,
a central processing unit for controlling the apheresis device,
at least one connection line for connection of at least one liquid container to the arterial line or the cell separator,
characterized in that
a bypass line branches off from the first plasma line and runs into the second plasma line,
a waste line goes off directly from the apheresis column or from the second plasma line in the direction of flow before the junction of the bypass line, and
at least one regeneration line which goes off from the at least one liquid container or from the at least one connection line and leads to the first plasma line in a direction of flow at or after the branch of the bypass line or runs directly into the apheresis column.