US 12,390,557 B2
Cryogel bioscaffold
Avnesh S. Thakor, Redwood City, CA (US); and Mehdi Razavi, Redwood City, CA (US)
Assigned to THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, Stanford, CA (US)
Appl. No. 17/610,598
Filed by The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US)
PCT Filed May 12, 2020, PCT No. PCT/US2020/032499
§ 371(c)(1), (2) Date Nov. 11, 2021,
PCT Pub. No. WO2020/232008, PCT Pub. Date Nov. 19, 2020.
Claims priority of provisional application 62/848,998, filed on May 16, 2019.
Prior Publication US 2022/0218875 A1, Jul. 14, 2022
Int. Cl. A61K 35/17 (2025.01); A61K 31/327 (2006.01); A61K 35/39 (2015.01); A61L 27/38 (2006.01); A61L 27/44 (2006.01); A61L 27/54 (2006.01); A61L 27/56 (2006.01); A61P 3/08 (2006.01); C12N 5/071 (2010.01); C12N 11/04 (2006.01)
CPC A61L 27/446 (2013.01) [A61K 35/17 (2013.01); A61K 35/39 (2013.01); A61L 27/3834 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); A61P 3/08 (2018.01); C12N 5/0677 (2013.01); C12N 5/0678 (2013.01); C12N 11/04 (2013.01); A61L 2300/40 (2013.01); C12N 2533/54 (2013.01)] 20 Claims
OG exemplary drawing
 
1. An oxygen-generating bioscaffold comprising:
a) a three-dimensional collagen-based cryogel matrix, wherein the cryogel matrix comprises a plurality of macropores and micropores; and
b) calcium peroxide (CPO), said CPO incorporated into the cryogel matrix, wherein the CPO produces oxygen upon exposure to water,
wherein the macropores have an average diameter ranging from about 150 μm to 800 μm, the micropores have an average diameter of 30 μm or less.