US 12,390,552 B2
Self-assembling peptide gel formulation and methods of use
Terrence Norchi, Natick, MA (US); Chirag Shah, North Attleboro, MA (US); and Rutledge Ellis-Behnke, Myrtle Beach, SC (US)
Assigned to Arch Biosurgery, Inc., Framingham, MA (US)
Filed by Arch Biosurgery, Inc., Framingham, MA (US)
Filed on Jan. 13, 2021, as Appl. No. 17/148,180.
Claims priority of provisional application 63/063,704, filed on Aug. 10, 2020.
Claims priority of provisional application 62/960,550, filed on Jan. 13, 2020.
Prior Publication US 2021/0213161 A1, Jul. 15, 2021
Int. Cl. A61L 27/22 (2006.01); A61L 27/52 (2006.01); A61L 27/58 (2006.01); C07K 7/08 (2006.01)
CPC A61L 27/22 (2013.01) [A61L 27/52 (2013.01); A61L 27/58 (2013.01); C07K 7/08 (2013.01); A61L 2400/04 (2013.01); A61L 2400/06 (2013.01); C07K 2319/735 (2013.01)] 24 Claims
 
1. A method comprising administering in vivo to a site in or on a subject in need thereof an effective amount of a biocompatible, injectable formulation comprising one or more self-assembling peptides which forms a lift or bulking agent having a duration of at least 30 minutes and an injection force of 13 N or greater,
wherein the self-assembling peptides comprise RADARADARADARADA (SEQ ID NO: 1) and/or EARAEARAEARAEARA (SEQ ID NO: 89),
in a concentration between about 2% up to about 6% w/v, to
separate or delineate tissues and/or organs or tumors;
lift, separate, or tunnel beneath or besides tissues, lesions, or a medical apparatus selected from wires, durable equipment, and closure devices;
form a cushion or lift at a target site comprising a lesion,
visualize or access tissue or margins during a procedure;
create an internal cast or structure that provides support around and/or between tissues or organs, enabling them to be stabilized, protected, recover, and/or heal,
provide a bulking agent;
provide a matrix for creation of new tissue; and/or
smooth wrinkles or scars,
wherein the formulation persists for at least one hour.