	US 12,390,522 B2
	Nucleic acids encoding human endogenous retrovirus K (HERV-k) envelope proteins containing modified immunosuppressive domains (ISD) and uses thereof
Peter Holst, Soeborg (DK); Christian Thirion, Munich (DE); and Lasse Neukirch, Flensburg (DE)
Assigned to INPROTHER APS, Copenhagen (DK)
Appl. No. 17/271,888
Filed by INPROTHER APS, Copenhagen (DK)
PCT Filed Aug. 30, 2019, PCT No. PCT/EP2019/073273 § 371(c)(1), (2) Date Feb. 26, 2021, PCT Pub. No. WO2020/043908, PCT Pub. Date Mar. 5, 2020.
Prior Publication US 2023/0181716 A1, Jun. 15, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/21 (2006.01); A61K 39/235 (2006.01); A61P 35/00 (2006.01); A61P 35/04 (2006.01); C07K 14/005 (2006.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01); A61K 39/00 (2006.01)

CPC A61K 39/21 (2013.01) [A61K 39/235 (2013.01); A61P 35/00 (2018.01); A61P 35/04 (2018.01); C07K 14/005 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); A61K 2039/525 (2013.01); A61K 2039/5258 (2013.01); A61K 2039/545 (2013.01); A61K 2039/585 (2013.01); C12N 2710/10043 (2013.01); C12N 2740/10022 (2013.01); C12N 2740/10023 (2013.01); C12N 2740/10034 (2013.01); C12N 2740/10071 (2013.01)]

15 Claims

1. A nucleic acid molecule encoding human endogenous retrovirus K (HERV-K) envelope protein or an immunogenic part thereof, wherein the immune-suppressive domain (ISD) of said protein contains at least one mutation that renders the ISD inactive, and wherein the at least one mutation in the inactivated ISD replaces Q525 with an alanine, wherein the numbering of said mutation is based on a HERV-K isolate comprising the sequence of any one of SEQ ID NO.: 9, 10, 11, 13, 17 and 21.