	US 12,390,521 B2
	Canine distemper vaccines and methods of treatment using the same
Sophia Reeder, Philadelphia, PA (US); Emma Reuschel, Philadelphia, PA (US); and David Weiner, Merion, PA (US)
Assigned to The Wistar Institute of Anatomy and Biology, Philadelphia, PA (US)
Appl. No. 17/287,698
Filed by THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY, Philadelphia, PA (US)
PCT Filed Oct. 25, 2019, PCT No. PCT/US2019/058023 § 371(c)(1), (2) Date Apr. 22, 2021, PCT Pub. No. WO2020/086939, PCT Pub. Date Apr. 30, 2020.
Claims priority of provisional application 62/751,002, filed on Oct. 26, 2018.
Prior Publication US 2021/0401970 A1, Dec. 30, 2021
Int. Cl. A61K 39/175 (2006.01); A61K 39/00 (2006.01); A61K 48/00 (2006.01); A61P 31/14 (2006.01)

CPC A61K 39/175 (2013.01) [A61K 48/0066 (2013.01); A61P 31/14 (2018.01); A61K 2039/525 (2013.01)]

20 Claims

1. An immunogenic composition comprising a nucleic acid molecule encoding at least one Canine Distemper Virus (CDV) antigen, wherein the nucleic acid molecule encodes a peptide comprising an amino acid sequence selected from the group consisting of

a) an amino acid sequence having at least 99% identity over an entire length of the amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO: 6, SEQ ID NO:8, SEQ ID NO: 10, SEQ ID NO: 12, SEQ ID NO: 14, SEQ ID NO: 16, SEQ ID NO: 18 and SEQ ID NO:20, and

b) the amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO: 4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO: 10, SEQ ID NO: 12, SEQ ID NO: 14, SEQ ID NO: 16, SEQ ID NO: 18 and SEQ ID NO:20.