US 12,390,504 B2
Polyphenol blend of curcumin extract and pomegranate extract and methods of improving immune response
Sonya Cropper, Noblesville, IN (US); and Nikeeta Kheradia, Noblesville, IN (US)
Assigned to Verdure Sciences, Inc., Noblesville, IN (US)
Filed by Verdure Sciences, Inc., Noblesville, IN (US)
Filed on Mar. 26, 2021, as Appl. No. 17/214,339.
Claims priority of provisional application 63/000,263, filed on Mar. 26, 2020.
Prior Publication US 2021/0299201 A1, Sep. 30, 2021
Int. Cl. A61K 36/185 (2006.01); A61K 9/107 (2006.01); A61K 31/12 (2006.01); A61P 37/06 (2006.01)
CPC A61K 36/185 (2013.01) [A61K 9/1075 (2013.01); A61K 31/12 (2013.01); A61P 37/06 (2018.01)] 19 Claims
 
1. A composition comprising a combination of a curcumin extract and a pomegranate extract, wherein said combination is a ratio of curcumin extract:pomegranate extract of 1:1 (w/w),
the curcumin extract containing 20-25% by weight Curcuma longa extract, 19-35% by weight maltodextrin, 10-20% by weight lecithin, 1-35% by weight stearic acid or salts thereof, 1-3% by weight ascorbyl palmitate, and optionally, 0.3-3% by weight silicon dioxide, the curcumin extract comprises solid lipid curcumin particles, the curcumin extract having a standardization of not less than about 20% total curcuminoids, and the pomegranate extract containing 100% by weight Punica granatum fruit extract, the pomegranate extract having a standardization of not less than about 10% punicalagins and 40% total polyphenols;
wherein radical scavenging activity measured by DPPH assay in micromole Trolox equivalents per gram (micromole TE/gram) is about 15% greater compared to a combination having a ratio of curcumin extract:pomegranate extract of 1:1.5 (w/w), and wherein levels of both inflammatory biomarkers IL-4 and IL-8 are increased relative to control when administered to a human subject.